[Et3NH][HSO4]-catalyzed one-pot, solvent-free synthesis and biological evaluation of α-amino phosphonates

被引：19

作者：

Shaikh, Mubarak H. ^{[1
]}

Subhedar, Dnyaneshwar D. ^{[1
]}

Khan, Firoz A. Kalam ^{[2
]}

Sangshetti, Jaiprakash N. ^{[2
]}

Shingate, Bapurao B. ^{[1
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India

[2] YB Chavan Coll Pharm, Dept Pharmaceut Chem, Dr Rafiq Zakaria Campus, Aurangabad 431001, Maharashtra, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 05期

关键词：

Ionic liquid; alpha-Aminophosphonate; Antifungal; Antioxidant; ADME prediction; KABACHNIK-FIELDS REACTION; IONIC LIQUIDS; CONVENIENT SYNTHESIS; LANTHANIDE TRIFLATE; SCHIFF-BASES; EFFICIENT; CATALYST; AMINOPHOSPHONATE; SOLUBILITY; REACTIVITY;

D O I：

10.1007/s11164-015-2348-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of dimethyl (phenyl(phenylamino)methyl)phosphonates and novel dimethyl ((phenylamino)(2-(prop-2-yn-1-yloxy)phenyl)methyl)phosphonates as potential antifungal agents were synthesized via one-pot, three-component condensation of aldehydes, amines and trimethyl phosphite in solvent-free conditions using [Et3NH][HSO4] as an efficient, eco-friendly and reusable catalyst. Compared to other methods, this new method consistently has advantages, including excellent yields, a short reaction time, mild reaction conditions and catalyst reusability. The newly synthesized propargylated ether containing alpha-amino phosphonates were evaluated for antifungal and antioxidant activity and were also analyzed for absorption, distribution, metabolism and excretion (ADME) properties. [GRAPHICS] .

引用

页码：5115 / 5131

页数：17

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