The Use of Biomarkers in Sepsis: A Systematic Review

被引：53

作者：

Giannakopoulos, Konstantinos ^{[1
]}

Hoffmann, Ursula ^{[1
]}

Ansari, Uzair ^{[1
]}

Bertsch, Thomas ^{[2
]}

Borggrefe, Martin ^{[1
]}

Akin, Ibrahim ^{[1
]}

Behnes, Michael ^{[1
]}

机构：

[1] Heidelberg Univ, Univ Med Ctr Mannheim UMM, Fac Med Mannheim, Dept Med 1, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany

[2] Paracelsus Med Univ, Gen Hosp Nuremberg, Inst Clin Chem, Lab Med & Transfus Med, Nurnberg, Germany

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2017年 / 18卷 / 06期

关键词：

Biomarkers; C-Reactive Protein (CPR); procalcitonin (PCT); prognosis; sepsis; septic shock; C-REACTIVE PROTEIN; POLYMERASE-CHAIN-REACTION; DISSEMINATED INTRAVASCULAR COAGULATION; INFLAMMATORY RESPONSE SYNDROME; NEUTROPHIL CD64 EXPRESSION; SEPTIC SHOCK; BACTERIAL-INFECTION; NATRIURETIC PEPTIDE; PROGNOSTIC VALUE; MATRIX-METALLOPROTEINASES;

D O I：

10.2174/1389201018666170601080111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Despite the extended laboratory and clinical study of sepsis, its diagnosis remains a clinical challenge. The initiation of sepsis activates many different biochemical and immunological pathways being expressed by alterations of various molecules in human tissues. The detection and measurement of the concentration of such molecules, known as biomarkers, may be a diagnostic tool of great significance for clinicians dealing with suspected sepsis. Additionally, biomarkers may predict patients' outcome and may play a role in monitoring response to therapy. Methods: Most relevant clinical and experimental biomarker studies on sepsis were retrieved and reviewed in this article. Results: Although many biomarkers were evaluated for the diagnosis and prognosis in sepsis, until now not one has been proven to be absolutely reliable in the clinical field. Currently C-reactive proteine (CPR) and procalcitonin (PCT) are used worldwide routinely, nevertheless their values may elevate in clinical settings without sepsis, while they often fail to provide reliable prediction of the patient outcome. Conclusion: This review outlines most relevant circulating biomarkers in sepsis.

引用

页码：499 / 507

页数：9

共 100 条

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