Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides

被引：2
|
作者：
Taniguchi, Yosuke [1 ]
Cao, Xiuming [1 ]
Sasaki, Shigeki [1 ]
机构：
[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 38期
基金：
日本学术振兴会;
关键词：
Deuterated thymine-d(4); Deuterated sugar; Deuterated thymidine-d(9); Deuterated oligodeoxynucleotides; D EXCHANGE-REACTION; DEUTERIUM-EXCHANGE; NMR STRUCTURE; RNA;
D O I：
10.1016/j.tetlet.2019.151037
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The efficient synthesis of the highly-deuterated thymidine-d(9) by the glycosylation reaction between a deuterated nucleobase and deuterated sugar is described. It is also incorporated into the oligonucleotides using a DNA synthesizer. Using this approach, it is possible to make highly-deuterated oligonucleotides for biological studies and structural analyses. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：4
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