A one-pot four-component (ABC2) synthesis of macrocycles

被引：94
|
作者：
Janvier, P [1 ]
Bois-Choussy, M [1 ]
Bienaymé, H [1 ]
Zhu, JP [1 ]
机构：
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 07期
关键词：
cyclophanes; isocyanicle ligands; macrocycles; multicomponent reactions; O ligands;
D O I：
10.1002/anie.200390216
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Six bonds are generated in one pot with concomitant creation of two oxazole groups as part of a new macrocycle. Simply mixing a diamine (2) and an aldehyde (3; 1:2 molar ratio) in MeOH at room temperature, followed by addition of diisocyanoacetamide (4) and heating at reflux, provides symmetric cyclophanes in good yield.
引用
收藏
页码：811 / 814
页数：4
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