Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children

被引：143

作者：

den Dekker, Herman T. ^{[1
,2
,3
]}

Voort, Agnes M. M. Sonnenschein-van der ^{[1
,2
,3
]}

de Jongste, Johan C. ^{[1
]}

Anessi-Maesano, Isabella ^{[6
,7
,8
]}

Arshad, S. Hasan ^{[9
,10
,11
]}

Barros, Henrique ^{[12
]}

Beardsmore, Caroline S. ^{[13
,14
]}

Bisgaard, Hans

Phar, Sofia Correia ^{[12
]}

Craig, Leone ^{[17
,18
]}

Devereux, Graham ^{[18
]}

van der Ent, C. Kors ^{[19
]}

Esplugues, Ana ^{[20
,21
,22
]}

Fantini, Maria P. ^{[23
]}

Flexeder, Claudia ^{[24
]}

Frey, Urs ^{[25
]}

Forastiere, Francesco ^{[26
]}

Gehring, Ulrike ^{[27
]}

Gori, Davide ^{[23
]}

van der Gugten, Anne C.

Henderson, A. John ^{[28
]}

Heude, Barbara ^{[29
,30
]}

Ibarluzea, Jesus ^{[22
,31
]}

Inskip, Hazel M. ^{[32
]}

Keil, Thomas ^{[33
,34
]}

Kogevinas, Manolis ^{[35
,36
,37
]}

Kreiner-Moller, Eskil ^{[15
,16
]}

Kuehni, Claudia E. ^{[38
]}

Lau, Susanne ^{[39
]}

Melen, Erik ^{[41
]}

Mommers, Monique ^{[42
]}

Morales, Eva ^{[16
,43
]}

Penders, John ^{[42
]}

Pike, Katy C. ^{[10
]}

Porta, Daniela

Reiss, Irwin K. ^{[4
]}

Roberts, Graham ^{[9
,10
,11
]}

Schmidt, Anne ^{[44
]}

Schultz, Erica S. ^{[40
,41
]}

Schulz, Holger

Sunyer, Jordi ^{[36
,43
]}

Torrent, Matias ^{[45
]}

Vassilaki, Maria ^{[46
]}

Wijga, Alet H. ^{[47
]}

Zabaleta, Carlos ^{[48
]}

Jaddoe, Vincent W. V. ^{[2
,3
,5
]}

Duijts, Liesbeth ^{[1
,2
,4
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Pediat, Div Resp Med, Sp 3435,POB 2060, NL-3000 CB Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Epidemiol, Sp 3435,POB 2060, NL-3000 CB Rotterdam, Netherlands

[3] Erasmus Univ, Med Ctr, Generat Study Grp R, Sp 3435,POB 2060, NL-3000 CB Rotterdam, Netherlands

[4] Erasmus Univ, Med Ctr, Dept Pediat, Div Neonatol, Sp 3435,POB 2060, NL-3000 CB Rotterdam, Netherlands

[5] Erasmus Univ, Med Ctr, Dept Pediat, Sp 3435,POB 2060, NL-3000 CB Rotterdam, Netherlands

[6] UMR S 707 INSERM Paris, EPAR, Paris, France

[7] Univ Paris 06, UMR S 707, EPAR, Paris, France

[8] Univ Paris 06, UMR S 707, EPAR, Paris, France

[9] St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport, Wight, England

[10] Univ Southampton, Fac Med, Southampton SO9 5NH, Hants, England

[11] Univ Hosp Southampton NHS Fdn Trust, NIHR Resp Biomed Res Unit, Southampton, Hants, England

[12] Univ Porto, Sch Med, Dept Clin Epidemiol Predict Med & Publ Hlth, Rua Campo Alegre 823, P-4100 Oporto, Portugal

[13] Univ Leicester, Div Child Hlth, Dept Infect Immun & Inflammat, Leicester, Leics, England

[14] Inst Lung Hlth, Leicester, Leics, England

[15] Univ Copenhagen, Copenhagen Prospect Studies Asthma Childhood COPS, Fac Hlth Sci, DK-1168 Copenhagen, Denmark

[16] Copenhagen Univ Hosp, Danish Pediat Asthma Ctr, Gentofte, Denmark

[17] Univ Aberdeen, Publ Hlth Nutr Res Grp, Aberdeen AB9 1FX, Scotland

[18] Univ Aberdeen, Appl Hlth Sci, Aberdeen AB9 1FX, Scotland

[19] Univ Med Ctr Utrecht, Dept Pediat Pulmonol, Wilhelmina Childrens Hosp, Utrecht, Netherlands

[20] Fac Nursing & Chiropody, Valencia, Spain

[21] FISABIO, Valencia, Spain

[22] CIBERESP, Madrid, Spain

[23] Univ Bologna, Dept Biomed & Neuromotor Sci, I-40126 Bologna, Italy

[24] Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany

[25] Univ Basel, Univ Childrens Hosp Basel UKBB, CH-4003 Basel, Switzerland

[26] Lazio Reg Hlth Serv, Dept Epidemiol, Rome, Italy

[27] Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TC Utrecht, Netherlands

[28] Univ Bristol, Sch Social & Community Med, Bristol BS8 1TH, Avon, England

[29] CESP Inserm, UMRS 1018, Team 10, Villejuif, France

[30] Univ Paris 11, UMRS 1018, Team 10, Villejuif, France

[31] Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[32] Univ Southampton, MRC Life Course Epidemiol Unit, Southampton Gen Hosp, Southampton SO9 5NH, Hants, England

[33] Charite, Med Ctr, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany

[34] Univ Wurzburg, Inst Clin Epidemiol & Biometry, Wurzburg, Germany

[35] Natl Sch Publ Hlth, Athens, GA USA

[36] CREAL, Barcelona, Spain

[37] Hosp Mar Med Res Inst IMIM, Barcelona, Spain

[38] Univ Bern, Inst Social & Prevent Med ISPM, CH-3012 Bern, Switzerland

[39] Charite, Dept Pediat Pneumol & Immunol, Med Ctr, D-13353 Berlin, Germany

[40] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden

[41] Karolinska Inst, Sachs Childrens Hosp, Stockholm, Sweden

[42] Maastricht Univ, Dept Epidemiol, CAPHRI Sch Publ Hlth & Primary Care, NL-6200 MD Maastricht, Netherlands

[43] Univ Pompeu Fabra, Barcelona, Spain

[44] Univ Bern, Div Resp Med, Dept Pediat, Inselspital, CH-3012 Bern, Switzerland

[45] IB SALUT Area Salut Menorca, Balearic Isl, Spain

[46] Univ Crete, Dept Social Med, Sch Med, Crete, France

[47] Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr Prevent & Hlth Serv, Bilthoven, Netherlands

[48] Nuestra Senora Antigua Hosp, OSAKIDETZA Basque Hlth Serv, San Sebastian, Spain

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2016年 / 137卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会; 美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

Preterm birth; low birth weight; infant growth; asthma; lung function; children; meta-analysis; BIRTH-WEIGHT; PRETERM BIRTH; RESPIRATORY-FUNCTION; AIRWAY FUNCTION; CHILDHOOD; AGE; ADOLESCENCE; STANDARDIZATION; ASSOCIATION; SPIROMETRY;

D O I：

10.1016/j.jaci.2015.08.050

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Children born preterm or with a small size for gestational age are at increased risk for childhood asthma. Objective: We sought to assess the hypothesis that these associations are explained by reduced airway patency. Methods: We used individual participant data of 24,938 children from 24 birth cohorts to examine and meta-analyze the associations of gestational age, size for gestational age, and infant weight gain with childhood lung function and asthma (age range, 3.9-19.1 years). Second, we explored whether these lung function outcomes mediated the associations of early growth characteristics with childhood asthma. Results: Children born with a younger gestational age had a lower FEV1, FEV1/forced vital capacity (FVC) ratio, and forced expiratory volume after exhaling 75% of vital capacity (FEF75), whereas those born with a smaller size for gestational age at birth had a lower FEV1 but higher FEV1/FVC ratio (P < .05). Greater infant weight gain was associated with higher FEV1 but lower FEV1/FVC ratio and FEF75 in childhood (P < .05). All associations were present across the full range and independent of other early-life growth characteristics. Preterm birth, low birth weight, and greater infant weight gain were associated with an increased risk of childhood asthma (pooled odds ratio, 1.34 [95% CI, 1.15-1.57], 1.32 [95% CI, 1.07-1.62], and 1.27 [95% CI, 1.21-1.34], respectively). Mediation analyses suggested that FEV1, FEV1/FVC ratio, and FEF75 might explain 7% (95% CI, 2% to 10%) to 45% (95% CI, 15% to 81%) of the associations between early growth characteristics and asthma. Conclusions: Younger gestational age, smaller size for gestational age, and greater infant weight gain were across the full ranges associated with childhood lung function. These associations explain the risk of childhood asthma to a substantial extent.

引用

页码：1026 / 1035

页数：10

共 52 条

[1] STANDARDIZATION OF SPIROMETRY - 1994 UPDATE [J].