PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes

被引：219

作者：

Ruepp, Andreas ^{[1
]}

Kowarsch, Andreas ^{[1
]}

Schmidl, Daniel ^{[1
,2
]}

Buggenthin, Felix ^{[1
]}

Brauner, Barbara ^{[1
]}

Dunger, Irmtraud ^{[1
]}

Fobo, Gisela ^{[1
]}

Frishman, Goar ^{[1
]}

Montrone, Corinna ^{[1
]}

Theis, Fabian J. ^{[1
,2
]}

机构：

[1] German Res Ctr Environm Hlth GmbH, Helmholtz Ctr Munich, Inst Bioinformat & Syst Biol MIPS, D-85764 Neuherberg, Germany

[2] Univ Technol Munich, Dept Math, D-85747 Garching, Germany

来源：

GENOME BIOLOGY | 2010年 / 11卷 / 01期

关键词：

CELL LINES; IDENTIFICATION; PROFILES; DATABASE; ENCODES; TARGETS; PROTEIN; TUMORS; RNAS;

D O I：

10.1186/gb-2010-11-1-r6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In recent years, microRNAs have been shown to play important roles in physiological as well as malignant processes. The PhenomiR database http://mips.helmholtz-muenchen.de/phenomir provides data from 542 studies that investigate deregulation of microRNA expression in diseases and biological processes as a systematic, manually curated resource. Using the PhenomiR dataset, we could demonstrate that, depending on disease type, independent information from cell culture studies contrasts with conclusions drawn from patient studies.

引用

页数：11

共 40 条

[31] MicroRNA expression profiling of thyroid tumors: Biological significance and diagnostic utility [J].

Nikiforova, Marina N. ;

Tseng, George C. ;

Steward, David ;

Diorio, Donna ;

Nikiforov, Yuri E. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (05) :1600-1608

[32] The database of experimentally supported targets: a functional update of TarBase [J].

Papadopoulos, Giorgos L. ;

Reczko, Martin ;

Simossis, Victor A. ;

Sethupathy, Praveen ;

Hatzigeorgiou, Artemis G. .

NUCLEIC ACIDS RESEARCH, 2009, 37 :D155-D158

[33] MicroRNAs accurately identify cancer tissue origin [J].

Rosenfeld, Nitzan ;

Aharonov, Ranit ;

Meiri, Eti ;

Rosenwald, Shai ;

Spector, Yael ;

Zepeniuk, Merav ;

Benjamin, Hila ;

Shabes, Norberto ;

Tabak, Sarit ;

Levy, Asaf ;

Lebanony, Danit ;

Goren, Yaron ;

Silberschein, Erez ;

Targan, Nurit ;

Ben-Ari, Alex ;

Gilad, Shlomit ;

Sion-Vardy, Netta ;

Tobar, Ana ;

Feinmesser, Meora ;

Kharenko, Oleg ;

Nativ, Ofer ;

Nass, Dvora ;

Perelman, Marina ;

Yosepovich, Ady ;

Shalmon, Bruria ;

Polak-Charcon, Sylvie ;

Fridman, Eddie ;

Avniel, Amir ;

Bentwich, Isaac ;

Bentwich, Zvi ;

Cohen, Dalia ;

Chajut, Ayelet ;

Barshack, Iris .

NATURE BIOTECHNOLOGY, 2008, 26 (04) :462-469

[34] THE CAENORHABDITIS-ELEGANS HETEROCHRONIC GENE LIN-14 ENCODES A NUCLEAR-PROTEIN THAT FORMS A TEMPORAL DEVELOPMENTAL SWITCH [J].

RUVKUN, G ;

GIUSTO, J .

NATURE, 1989, 338 (6213) :313-319

[35] Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia [J].

Saumet, Anne ;

Vetter, Guillaume ;

Bouttier, Manuella ;

Portales-Casamar, Elodie ;

Wasserman, Wyeth W. ;

Maurin, Thomas ;

Mari, Bernard ;

Barbry, Pascal ;

Vallar, Laurent ;

Friederich, Evelyne ;

Arar, Khalil ;

Cassinat, Bruno ;

Chomienne, Christine ;

Lecellier, Charles-Henri .

BLOOD, 2009, 113 (02) :412-421

[36] Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia [J].

Schotte, D. ;

Chau, J. C. K. ;

Sylvester, G. ;

Liu, G. ;

Chen, C. ;

van der Velden, V. H. J. ;

Broekhuis, M. J. C. ;

Peters, T. C. J. M. ;

Pieters, R. ;

den Boer, M. L. .

LEUKEMIA, 2009, 23 (02) :313-322

[37] Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival [J].

Takamizawa, J ;

Konishi, H ;

Yanagisawa, K ;

Tomida, S ;

Osada, H ;

Endoh, H ;

Harano, T ;

Yatabe, Y ;

Nagino, M ;

Nimura, Y ;

Mitsudomi, T ;

Takahashi, T .

CANCER RESEARCH, 2004, 64 (11) :3753-3756

[38] A microRNA expression signature of human solid tumors defines cancer gene targets [J].

Volinia, S ;

Calin, GA ;

Liu, CG ;

Ambs, S ;

Cimmino, A ;

Petrocca, F ;

Visone, R ;

Iorio, M ;

Roldo, C ;

Ferracin, M ;

Prueitt, RL ;

Yanaihara, N ;

Lanza, G ;

Scarpa, A ;

Vecchione, A ;

Negrini, M ;

Harris, CC ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (07) :2257-2261

[39] A computational screen for mouse signaling pathways targeted by microRNA clusters [J].

Xu, Jianzhen ;

Wong, Chiwai .

RNA, 2008, 14 (07) :1276-1283

[40] microRNAs exhibit high frequency genomic alterations in human cancer [J].

Zhang, Lin ;

Huang, Jia ;

Yang, Nuo ;

Greshock, Joel ;

Megraw, Molly S. ;

Giannakakis, Antonis ;

Liang, Shun ;

Naylor, Tara L. ;

Barchetti, Andrea ;

Ward, Michelle R. ;

Yao, George ;

Medina, Angelical ;

O'Brien-Jenkins, Ann ;

Katsaros, Dionyssios ;

Hatzigeorgiou, Artemis ;

Gimotty, Phyllis A. ;

Weber, Barbara L. ;

Coukos, George .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (24) :9136-9141

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