Oxytocin depresses spontaneous γ-aminobutyric acid-ergic inhibitory postsynaptic currents in cultured mitral cells of the rat olfactory bulb by a presynaptic mechanism

被引：11
作者：
Osako, Y
Otsuka, T
Taniguchi, M
Oka, T
Kaba, H [1 ]
机构：
[1] Kochi Med Sch, Dept Physiol, Nanko Ku, Kochi 7838505, Japan
[2] Kagoshima Univ, Fac Agr, Dept Vet Physiol, Kagoshima 8900065, Japan
来源：
NEUROSCIENCE LETTERS | 2000年 / 289卷 / 01期
关键词：
gamma-aminobutyric acid; inhibitory postsynaptic currents; mitral cell; oxytocin; olfactory bulb; presynaptic; primary culture;
D O I：
10.1016/S0304-3940(00)01235-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Oxytocin (OT) modulation of synaptic transmission between olfactory bulb neurones has been implicated in the induction of maternal behaviour, but the mechanism of action is unknown. We examined the action of OT on gamma-amino butyric acid(A) (GABA(A)) receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) in cultured mitral/tufted (M/T) cells with the use of whole-cell patch-clamp recordings. OT reversibly reduced the frequency of sIPSCs without affecting the amplitudes. The effect of OT on sIPSCs was mimicked by the OT receptor agonist [Thr(4),Gly(7)]-OT in a reversible manner and blocked by the OT receptor antagonist desGly-NH29, d(CH2)(5)-[Tyr(Me)(2),Thr(4)]-ornithine-vasotocin. OT has no effect, however, on the membrane currents evoked by exogenous application of GABA. These results demonstrate that OT depresses GABA(A) receptor-mediated sIPSCs in MTT cells by a presynaptic mechanism. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.
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收藏
页码：25 / 28
页数：4
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