Nicergoline reverts haloperidol-induced loss of detoxifying-enzyme activity

被引：5

作者：

Vairetti, M

Ferrigno, A

Canonico, PL

Battaglia, A

Bertè, F

Richelmi, P

机构：

[1] Univ Pavia, Dept Internal Med & Therapeut, I-27100 Pavia, Italy

[2] Univ Piemonte, Dept DISCAFF, Novara, Italy

[3] Pfizer Italia Srl, Dept Med, Rome, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 505卷 / 1-3期

关键词：

haloperidol; nicergoline; glutathione reductase; glutathione peroxidase; superoxide dismutase;

D O I：

10.1016/j.ejphar.2004.10.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We evaluated the effects of nicergoline on antioxidant defense enzymes (detoxifying enzymes), during chronic treatment with haloperidol in rats. Chronic use of haloperidol (10 weeks, 1.5 mg/kg/day) induces a significant decrease in glutathione reductase, glutathione peroxidase and superoxide dismutase activity, in selected areas of the brain. Co-administration of nicergoline (20 days, 10 mg/kg/day) significantly restored the activity of these enzymes to levels comparable to those observed in control rats. These observations suggest beneficial effects of nicergoline in the prevention and in the treatment of haloperidol-induced side effects. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：121 / 125

页数：5

共 24 条

[1] Protein thiol oxidation by haloperidol results in inhibition of mitochondrial complex I in brain regions: comparison with atypical antipsychotics [J].