Microwave-Assisted Regioselective Suzuki Coupling of 2,4-Dichloropyrimidines with Aryl and Heteroaryl Boronic Acids

被引：4

作者：

Dolsak, Ana ^{[1
]}

Mrgole, Kristjan ^{[1
]}

Sova, Matej ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Pharm, Askerceva 7, Ljubljana 1000, Slovenia

来源：

CATALYSTS | 2021年 / 11卷 / 04期

关键词：

cross-coupling; Suzuki; palladium; pyrimidines; synthesis; microwave-assisted;

D O I：

10.3390/catal11040439

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Suzuki coupling reaction has been often used for the preparation of a diverse set of substituted pyrimidines. In this study, the Suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids was investigated. A thorough screening of reaction conditions and the use of microwave irradiation led to a very efficient and straightforward synthetic procedure providing C4-substituted pyrimidines in good to excellent yields. Short reaction time (15 min) and extremely low catalyst loading (0.5 mol%) are the main advantages of our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be used for quick and low-cost regioselective preparation of substituted pyrimidine rings.

引用

页数：16

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