The Human Endocrine Pancreas: New Insights on Replacement and Regeneration

被引：20

作者：

Dominguez-Bendala, Juan ^{[1
,2
,3
]}

Lanzoni, Giacomo ^{[1
]}

Klein, Dagmar ^{[1
]}

Alvarez-Cubela, Silvia ^{[1
]}

Pastori, Ricardo L. ^{[1
,4
,5
]}

机构：

[1] Univ Miami, Miller Sch Med, Diabet Res Inst, Miami, FL 33136 USA

[2] Univ Miami, Miller Sch Med, Dept Surg, Miami, FL 33136 USA

[3] Univ Miami, Miller Sch Med, Dept Cell Biol & Anat, Miami, FL 33136 USA

[4] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

[5] Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33136 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2016年 / 27卷 / 03期

关键词：

INSULIN-PRODUCING CELLS; BETA-CELL; STEM-CELLS; ACINAR-CELL; IN-VITRO; ADULT-MOUSE; EFFICIENT DIFFERENTIATION; EXOCRINE CELLS; PROGENITORS; TRANSPLANTATION;

D O I：

10.1016/j.tem.2015.12.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Islet transplantation is an effective cell therapy for type 1 diabetes (T1 D) but its clinical application is limited due to shortage of donors. After a decade-long period of exploration of potential alternative cell sources, the field has only recently zeroed in on two of them as the most likely to replace islets. These are pluripotent stem cells (PSCs) (through directed differentiation) and pancreatic non-endocrine cells (through directed differentiation or reprogramming). Here we review progress in both areas, including the initiation of Phase I/II clinical trials using human embryonic stem cell (hESc)-derived progenitors, advances in hESc differentiation in vitro, novel insights on the developmental plasticity of the pancreas, and groundbreaking new approaches to induce 13 cell conversion from the non-endocrine compartment without genetic manipulation.

引用

页码：153 / 162

页数：10

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