Safety of classical swine fever virus vaccine strain LOM in pregnant sows and their offspring

被引：19

作者：

Lim, Seong-In ^{[1
]}

Song, Jae-Young ^{[1
]}

Kim, Jaejo ^{[1
]}

Hyun, Bang-Hun ^{[1
]}

Kim, Ha-Young ^{[1
]}

Cho, In-Soo ^{[1
]}

Kim, Byounghan ^{[1
]}

Woo, Gye-Hyeong ^{[2
]}

Lee, Jung-Bok ^{[3
]}

An, Dong-Jun ^{[1
]}

机构：

[1] Anim & Plant Quarantine Agcy QIA, 175 Anayangro Manangu Anyangsi, Gyeonggido 430824, South Korea

[2] Semyung Univ, Dept Clin Lab Sci, Jecheon, Semyung Ro 65, Jecheon 390711, Chungbuk, South Korea

[3] Konkuk Univ, 1 Hawayangdong Gwangjingu, Seoul 143701, South Korea

来源：

VACCINE | 2016年 / 34卷 / 17期

关键词：

Classical swine fever virus; LOM strain; Pregnant sows; Safety; HOG-CHOLERA VIRUS; INFECTION; PIGS;

D O I：

10.1016/j.vaccine.2016.02.062

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study aimed to evaluate the safety of the classical swine fever virus (CSFV) vaccine strain LOM in pregnant sows. Pregnant sows with free CSFV antibody were inoculated with a commercial LOM vaccine during early pregnancy (day 38; n=3) or mid-pregnancy (days 49-59; n=11). In pregnant sows vaccinated during the early stages of gestation, abortion (day 109) was observed in one case, with two stillbirths and seven mummified fetuses. The viability of live-born piglets was 34.9% in sows vaccinated during mid-pregnancy compared with 81.8%in the control group. Post-mortem examination of the organs of the sows and piglets did not reveal any pathological lesions caused by CSFV; however, CSFV RNA was detected in the organs of several vaccinated sows and their litters. The LOM strain was transmitted from sows with free CSFV antibody to their fetus, but did not appear to induce immune tolerance in the offspring from vaccinated pregnant sows. Side effects were not observed in pregnant sows with antibody to the LOM strain: transmission from sow to their litters and stillbirth or mummified fetuses. The LOM strain may induce sterile immunity and provide rapid, long-lasting, and complete protection against CSFV; however, it should be contraindicated in pregnant sows due to potential adverse effects in pregnant sows with free CSFV antibody. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2021 / 2026

页数：6