Ecto-5′-Nucleotidase-Positive Cells in the Choroid and Ciliary Body of the Rat Eye

被引：4

作者：

Braun, Johann Sebastian ^{[1
,2
]}

机构：

[1] Charite, Dept Neurol, D-13353 Berlin, Germany

[2] UAE Univ, Div Neurol, Dept Internal Med, Al Ain 17666, U Arab Emirates

来源：

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2010年 / 293卷 / 03期

关键词：

ecto-5 '-nucleotidase; immunohistochemistry; ciliary body; choroid; ENDOTHELIAL-CELLS; BLOOD-FLOW; ADENOSINE; MEMBRANE; ECTONUCLEOTIDASES; 5'-NUCLEOTIDASE; LOCALIZATION; METABOLISM; RECEPTORS; RESPONSES;

D O I：

10.1002/ar.21080

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Adenosine is known to exert multiple functions within the eye. The aim of this report was to find out if adenosine can be produced locally in the choroid and ciliary body. Therefore, I investigated the distribution of ecto-5'-nucleotidase (5'-NT), the key enzyme for the production of extracellular adenosine. This report provides evidence that 5'-NT is expressed in the choroid and in the ciliary body (and its processes) of the rat eye, predominantly in endothelial cells. These locations of 5'-NT indicate strategically important production sites of adenosine regulating choroid and ciliary body functions (e.g., blood flow, aqueous fluid production, and immune response). Anat Rec, 293:379-382, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：379 / 382

页数：4

共 50 条

[41] Upregulation of Ecto-5′-Nucleotidase by Rosuvastatin Increases the Vasodilator Response to Ischemia [J].

Meijer, Patrick ;

Wouters, Constantijn W. ;

van den Broek, Petra H. H. ;

de Rooij, Maarten ;

Scheffer, Gert Jan ;

Smits, Paul ;

Rongen, Gerard A. .

HYPERTENSION, 2010, 56 (04) :722-727

[42] Structural and Modeling Studies on ecto-5′-nucleotidase Aiding in Inhibitor Design [J].

Furtmann, Norbert ;

Bajorath, Juergen .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2015, 15 (01) :34-40

[43] Tyramine produces interstitial adenosine-mediated activation of ecto-5′-nucleotidase in rat heart in vivo [J].

Obata, T ;

Yamanaka, Y .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 374 (01) :25-31

[44] Ecto-5′-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature [J].

Yegutkin, Gennady G. ;

Auvinen, Kaisa ;

Rantakari, Pia ;

Hollmen, Maija ;

Karikoski, Marika ;

Grenman, Reidar ;

Elima, Kati ;

Jalkanen, Sirpa ;

Salmi, Marko .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (02) :562-573

[45] Oxidative stress inactivates ecto-5′-nucleotidase by inhibiting protein kinase C in rat hearts in vivo [J].

Obata, Toshio ;

Nakashima, Michiko .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2017, 805 :125-130

[46] Reserpine attenuates interstitial adenosine-mediated activation of ecto-5′-nucleotidase in rat hearts in vivo [J].

Obata, T ;

Yamanaka, Y .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 375 (02) :333-339

[47] Exacerbation of Allergic Airway Inflammation in Mice Lacking ECTO-5′-Nucleotidase (CD73) [J].

Caiazzo, Elisabetta ;

Cerqua, Ida ;

Riemma, Maria Antonietta ;

Turiello, Roberta ;

Ialenti, Armando ;

Schrader, Jurgen ;

Fiume, Giuseppe ;

Caiazza, Carmen ;

Roviezzo, Fiorentina ;

Morello, Silvana ;

Cicala, Carla .

FRONTIERS IN PHARMACOLOGY, 2020, 11

[48] Fibroblast growth factor 2 modulates extracellular purine metabolism by upregulating ecto-5′-nucleotidase and adenosine deaminase in cultured rat spinal cord astrocytes [J].

Eguchi, Ryota ;

Yamaguchi, Soichiro ;

Otsuguro, Ken-ichi .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2019, 139 (02) :98-104

[49] Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge [J].

Caiazzo, Elisabetta ;

Cerqua, Ida ;

Turiello, Roberta ;

Riemma, Maria Antonietta ;

De Palma, Giacomo ;

Ialenti, Armando ;

Roviezzo, Fiorentina ;

Morello, Silvana ;

Cicala, Carla .

BIOMOLECULES, 2022, 12 (05)

[50] Activation of ecto-5′-nucleotidase in the blood and hearts of patients with chronic heart failure [J].

Fujita, Masashi ;

Asakura, Masanori ;

Sanada, Shoji ;

Funaya, Hiroharu ;

Tsukamoto, Osamu ;

Komamura, Kazuo ;

Asanuma, Hiroshi ;

Taketani, Satoshi ;

Isomura, Tadashi ;

Nakamaru, Kenji ;

Furukawa, Hidehiko ;

Sawa, Yoshiki ;

Hori, Masatsugu ;

Kitakaze, Masafumi .

JOURNAL OF CARDIAC FAILURE, 2008, 14 (05) :426-430

← 1 2 3 4 5 →