Ecto-5′-Nucleotidase-Positive Cells in the Choroid and Ciliary Body of the Rat Eye

被引：4

作者：

Braun, Johann Sebastian ^{[1
,2
]}

机构：

[1] Charite, Dept Neurol, D-13353 Berlin, Germany

[2] UAE Univ, Div Neurol, Dept Internal Med, Al Ain 17666, U Arab Emirates

来源：

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2010年 / 293卷 / 03期

关键词：

ecto-5 '-nucleotidase; immunohistochemistry; ciliary body; choroid; ENDOTHELIAL-CELLS; BLOOD-FLOW; ADENOSINE; MEMBRANE; ECTONUCLEOTIDASES; 5'-NUCLEOTIDASE; LOCALIZATION; METABOLISM; RECEPTORS; RESPONSES;

D O I：

10.1002/ar.21080

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Adenosine is known to exert multiple functions within the eye. The aim of this report was to find out if adenosine can be produced locally in the choroid and ciliary body. Therefore, I investigated the distribution of ecto-5'-nucleotidase (5'-NT), the key enzyme for the production of extracellular adenosine. This report provides evidence that 5'-NT is expressed in the choroid and in the ciliary body (and its processes) of the rat eye, predominantly in endothelial cells. These locations of 5'-NT indicate strategically important production sites of adenosine regulating choroid and ciliary body functions (e.g., blood flow, aqueous fluid production, and immune response). Anat Rec, 293:379-382, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：379 / 382

页数：4

共 50 条

[31] Ecto-5′-nucleotidase is not required for ischemic preconditioning in rabbit myocardium in situ [J].

Miki, T ;

Miura, T ;

Bünger, R ;

Suzuki, K ;

Sakamoto, J ;

Shimamoto, K .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1998, 275 (04) :H1329-H1337

[32] Analysis of the NTPDase and ecto-5′-nucleotidase profiles in serum-limited Trichomonas vaginalis [J].

Frasson, Amanda Piccoli ;

Charao, Mariele Feiffer ;

Rosemberg, Denis Broock ;

de Souza, Ana Paula ;

Garcia, Solange Cristina ;

Bonorino, Cristina ;

Bogo, Mauricio Reis ;

De Carli, Geraldo Attilio ;

Tasca, Tiana .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2012, 107 (02) :170-177

[33] EFFECT OF DIPYRIDAMOLE ON GLOMERULAR MESANGIAL CELL ECTO-5'-NUCLEOTIDASE EXPRESSION [J].

STEFANOVIC, V ;

SAVIC, V ;

VLAHOVIC, P .

EXPERIENTIA, 1994, 50 (10) :943-946

[34] Ecto-5'-nucleotidase and intestinal ion secretion by enteropathogenic Escherichia coli [J].

Crane, John K. ;

Shulgina, Irina ;

Naeher, Tonniele M. .

PURINERGIC SIGNALLING, 2007, 3 (03) :233-246

[35] Ecto-5′-nucleotidase and intestinal ion secretion by enteropathogenic Escherichia coli [J].

John K. Crane ;

Irina Shulgina ;

Tonniele M. Naeher .

Purinergic Signalling, 2007, 3 :233-246

[36] Identification of Small Molecule Sulfonic Acids as Ecto-5′-Nucleotidase Inhibitors [J].

Raza, Rabia ;

Saeed, Aamer ;

Lecka, Joanna ;

Sevigny, Jean ;

Iqbal, Jamshed .

MEDICINAL CHEMISTRY, 2012, 8 (06) :1133-1139

[37] Cardioprotection due to preconditioning correlates with increased ecto-5'-nucleotidase activity [J].

Minamino, T ;

Kitakaze, M ;

Morioka, T ;

Node, K ;

Komamura, K ;

Takeda, H ;

Inoue, M ;

Hori, M ;

Kamada, T .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 270 (01) :H238-H244

[38] Lack of ecto-5′-nucleotidase (CD73) promotes arteriogenesis [J].

Boering, Yang Chul ;

Floegel, Ulrich ;

Jacoby, Christoph ;

Heil, Matthias ;

Schaper, Wolfgang ;

Schrader, Juergen .

CARDIOVASCULAR RESEARCH, 2013, 97 (01) :88-96

[39] Tenascin C interacts with Ecto-5′-nucleotidase (eN) and regulates adenosine generation in cancer cells [J].

Sadej, Rafal ;

Inail, Kunihiro ;

Rajfur, Zenon ;

Ostapkowicz, Anna ;

Kohler, Jon ;

Skladanowski, Andrzej C. ;

Mitchell, Beverly S. ;

Spychala, Jozef .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2008, 1782 (01) :35-40

[40] Exposure to human blood inactivates swine endothelial ecto-5′-nucleotidase [J].

Khalpey, Z ;

Kalsi, K ;

Yuen, A ;

Karbowska, J ;

Kochan, Z ;

Slominska, EM ;

Forni, M ;

Bacci, M ;

Macherini, M ;

Batten, P ;

Lavitrano, M ;

Yacoub, MH ;

Smolenski, RT .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2005, 24 (04) :271-274

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