The recent progresses in shRNA-nanoparticle conjugate as a therapeutic approach

被引：26
作者：
Acharya, Rituparna [1 ]
机构：
[1] Jadavpur Univ, Sch Biosci & Engn, 188 Raja SC Mullick Rd, Kolkata 700032, India
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 104卷
关键词：
shRNA; Nanoparticle; PEG; PEI; PLGA; FOCAL ADHESION KINASE; SHORT HAIRPIN RNA; ENDOTHELIAL GROWTH-FACTOR; BCL-XL SHRNA; SOLID LIPID NANOPARTICLES; SMALL INTERFERING RNA; CELLS IN-VITRO; CO-DELIVERY; PROSTATE-CANCER; OVARIAN-CANCER;
D O I：
10.1016/j.msec.2019.109928
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The recent trend of gene therapy is using short hairpin RNA conjugated with different types of nanoparticles. shRNAs have a significant role in gene silencing and have a promising role in treating several genetic and infectious diseases. There are several drawbacks of delivering bare shRNA in the blood as they are fragile in nature and readily degradable. To overcome this problem shRNAs can be conjugated with nanoparticles for a safe deliver. In this article several nanoparticles are mentioned which play significant role in delivery of this payload. On one hand they protect the shRNA from degradation on the other they help to penetrate this large molecule in to the cell. Some of these nanoconjugates are in clinical trials and have a promising role in treatment of diseases.
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页数：8
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