Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon

被引：20

作者：

Hoshino, Akemi ^{[1
]}

Fujii, Hodaka ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

来源：

FEBS LETTERS | 2007年 / 581卷 / 05期

关键词：

cytokine; IL-3; immediate-early genes; expression regulation;

D O I：

10.1016/j.febslet.2007.01.083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokines control cell differentiation, proliferation, and function by regulating gene expression program. Physiological roles and induction mechanisms of cytokine-inducible genes are not fully understood. Here, we identified a novel immediate-early cytokine-responsive gene, cyclon (atokine-induced protein with coiled-coil domain), which is induced in a hematopoietic cell line by interleukin 3 (IL-3). cyclon gene encodes a phosphorylated nuclear protein consisting of repetitive sequences in the amino-terminus and a coiled-coil domain in the carboxyl-terminus. A novel transient reporter assay revealed that mouse cyclon promoter contains redundant elements for IL-3-induced gene expression. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：975 / 980

页数：6

相关论文

共 12 条

[1] Coiled coils: a highly versatile protein folding motif [J].

Burkhard, P ;

Stetefeld, J ;

Strelkov, SV .

TRENDS IN CELL BIOLOGY, 2001, 11 (02) :82-88

[2] Inducible translocation trap: A system for detecting inducible nuclear translocation [J].

Hoshino, A ;

Matsumura, S ;

Kondo, K ;

Hirst, JA ;

Fujii, H .

MOLECULAR CELL, 2004, 15 (01) :153-159

[3] Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain [J].

Hoshino, Akerni ;

Saint Fleur, Shella ;

Fujii, Hodaka .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 346 (03) :1062-1066

[4]

HROMAS R, 1991, J BIOL CHEM, V266, P14183

[5] CRITICAL ROLE OF THE INTERLEUKIN-2 (IL-2) RECEPTOR GAMMA-CHAIN-ASSOCIATED JAK3 IN THE IL-2-INDUCED C-FOS AND C-MYC, BUT NOT BCL-2, GENE INDUCTION [J].

KAWAHARA, A ;

MINAMI, Y ;

MIYAZAKI, T ;

IHLE, JN ;

TANIGUCHI, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (19) :8724-8728

[6]

Leonard W.J., 2003, FUNDAMENTAL IMMUNOLO, P701

[7] 3 DISTINCT IL-2 SIGNALING PATHWAYS MEDIATED BY BCL-2, C-MYC, AND LCK COOPERATE IN HEMATOPOIETIC-CELL PROLIFERATION [J].

MIYAZAKI, T ;

LIU, ZJ ;

KAWAHARA, A ;

MINAMI, Y ;

YAMADA, K ;

TSUJIMOTO, Y ;

BARSOUMIAN, EL ;

PERLMUTTER, RM ;

TANIGUCHI, T .

CELL, 1995, 81 (02) :223-231

[8] PEF-BOS, A POWERFUL MAMMALIAN EXPRESSION VECTOR [J].

MIZUSHIMA, S ;

NAGATA, S .

NUCLEIC ACIDS RESEARCH, 1990, 18 (17) :5322-5322

[9] STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells [J].

Nosaka, T ;

Kawashima, T ;

Misawa, K ;

Ikuta, K ;

Mui, ALF ;

Kitamura, T .

EMBO JOURNAL, 1999, 18 (17) :4754-4765

[10] CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3 [J].

Nosaka, Y ;

Arai, A ;

Miyasaka, N ;

Miura, O .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) :30154-30162