C-Reactive Protein and Albumin Ratio Predicts Mortality in Elderly Patients Aged Eighty Years and Over with Non-ST-Segment Elevation Myocardial Infarction

Introduction: To explore the prognostic importance for admission of C-reactive protein (CRP)/albumin ratio (CAR) in elderly patients aged 80 years over who presented with non-ST elevation myocardial infarction (non-STEMI). Methods: This retrospective, observational research was related to the clinical data of 528 elderly non-STEMI patients. The study population was categorized based on CAR tertiles as T1, T2, and T3 groups. The CAR was obtained by dividing CRP to albumin level. The main outcome of the research was the in-hospital mortality. Results: The in-hospital mortality rate during index hospitalization was 5% (n=27 patients). Cases included in theT3 tertile had significantly higher incidence of cardiopulmonary arrest, cardiac mortality, and all-cause mortality during the index hospitalization [(15% vs 4% vs 0.5%), (10% vs 1% vs 0%), and (13% vs 2% vs 0%), respectively, p<0.05 each]. In multivariate analysis, chronic renal failure, Killip class of >1 on admission, revascularization, and CAR (odds ratio: 1.47, 95% confidence intervals: 1.23-1.75, p<0.01) were independent parameters related with in-hospital mortality. A receiver operating characteristics curve analysis revealed that CAR >1.12 predicted in-hospital mortality with a sensitivity of 85% and specificity of 77% (area under the curve: 0.813, p<0.01). Conclusion: In this clinical research, we observed that CAR may be a significant predictor of mortality in elderly patients who were aged 80 years and over with non-STEMI.