MiR-378 suppresses prostate cancer cell growth through downregulation of MAPK1 in vitro and in vivo

被引：60

作者：

Chen, Qi-guang ^{[1
]}

Zhou, Wei ^{[2
]}

Han, Tao ^{[3
]}

Du, Shu-qi ^{[1
]}

Li, Zhen-hua ^{[1
]}

Zhang, Zhe ^{[1
]}

Shan, Guang-yi ^{[4
]}

Kong, Chui-ze ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing St 155, Shenyang 110001, Liaoning, Peoples R China

[2] Gen Hosp Shenyang Mil Reg, Dept Diagnost Radiol, Shenyang, Liaoning, Peoples R China

[3] Gen Hosp Shenyang Mil Reg, Dept Oncol, Shenyang, Liaoning, Peoples R China

[4] LiaoNing Canc Hosp & Inst, Dept Urol, Shenyang, Liaoning, Peoples R China

来源：

TUMOR BIOLOGY | 2016年 / 37卷 / 02期

关键词：

Prostate cancer; microRNA; miR-378; MAPK1; MICRORNAS; PROGRESSION; EXPRESSION; SURVIVAL; GENES;

D O I：

10.1007/s13277-015-3996-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer is one of the biggest health problems for the aging male. To the present, the roles of dysregulated microRNAs in prostate cancer are still unclear. Here, we evaluated the anti-proliferative role of miR-378 in prostate cancer. And, we found that the expression of miR-378 was significantly downregulated in clinical prostate cancer tissues. In vitro assay suggested that overexpression of miR-378-suppressed prostate cancer cell migration and invasion promoted cell apoptosis. Furthermore, we identified and validated MAPK1 as a direct target of miR-378. Ectopic expression of MAPK1 rescues miR-378-suppressed cell migration and invasion. In vivo assay demonstrated that the stably miR-378-overexpressed prostate cancer cells displayed a significantly reduction in tumor growth. Taken together, our data suggested that miR-378 may act as a potential therapeutic target against human prostate cancer.

引用

页码：2095 / 2103

页数：9

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