Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia

被引：27

作者：

Evans, MF ^{[1
]}

Koreth, J ^{[1
]}

Bakkenist, CJ ^{[1
]}

Herrington, CS ^{[1
]}

McGee, JOD ^{[1
]}

机构：

[1] John Radcliffe Hosp, Nuffield Dept Pathol & Bacteriol, Oxford OX3 9DU, England

来源：

ONCOGENE | 1998年 / 16卷 / 19期

关键词：

human chromosome 11; clonality; HPV; cervix;

D O I：

10.1038/sj.onc.1202039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. GIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six tone with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.

引用

页码：2557 / 2564

页数：8

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