2019 Coronavirus disease (COVID-19): contribution of rheumatology

被引:1
|
作者
Nasonov, Evgeny L. [1 ,2 ]
机构
[1] Nasonova Res Inst Rheumatol, Moscow, Russia
[2] Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow, Russia
关键词
COVID-19; immune-mediated rheumatic diseases; AUTOIMMUNE-DISEASES;
D O I
10.26442/00403660.2021.05.200799
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The 2019 coronavirus disease (COVID-19) pandemic become a major challenge for humanity and a unique opportunity to get an idea of the real achievements of modern biology and medicine. In the course of the pandemic, a large number of new fundamental and medical issues have been revealed regarding the relationship between viral infection and many common chronic non-infectious diseases, among which immune-mediated rheumatic diseases (IMRD) occupy an important position. It is now well known that SARS-CoV-2 infection is accompanied by a wide range of extrapulmonary clinical and laboratory disorders, some of which are characteristic of IMRD and other autoimmune and autoinflammatory diseases in humans. The most severe consequence of alterations in regulation of the immunity in COVID-19 and IMRD is the so-called cytokine storm syndrome, which is defined as COVID-19-associated hyperinflammatory syndrome in COVID-19, and as macrophage activation syndrome in IMRD. The COVID-19-associated hyperinflammatory syndrome was used as a reason for drug repurposing and off-label use of a wide range of anti-inflammatory drugs, which have been specially developed for the treatment of IMRD over the past 20 years. Common immunopathological mechanisms and approaches to pharmacotherapy in COVID-19 and IMRD determined the unique place of rheumatology among medical specialties contributing to combat the COVID-19 pandemic. The article provides the basic provisions of the International and National Association of Rheumatologists and the Association of Rheumatologists of Russia (ARR) recommendations for management of patients with IMRD during the COVID-19 pandemic.
引用
收藏
页码:537 / 550
页数:14
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