RNA polymerase - An important molecular target of triptolide in cancer cells

被引：59

作者：

Pan, Jingxuan ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pathophysiol, Guangzhou 510089, Guangdong, Peoples R China

来源：

CANCER LETTERS | 2010年 / 292卷 / 02期

基金：

国家高技术研究发展计划(863计划);

关键词：

Triptolide; RNA polymerase; Molecular target; Cancer; CHRONIC MYELOGENOUS LEUKEMIA; TRIPTERYGIUM-WILFORDII HOOK; HUMAN MAST-CELLS; ONCOGENE ADDICTION; BCR-ABL; TUMOR-CELLS; APOPTOSIS; INHIBITORS; PROTEIN; KIT;

D O I：

10.1016/j.canlet.2009.11.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Triptolide, a diterpenoid triepoxide, is the key biological component of Tripterygium wilfordu Hook. f which was used in traditional Chinese medicine for centuries to treat inflammation anti autoimmune diseases Triptolide has shown potent activity in not only anti-inflammation and immune modulation, but also antiproliferative and proapoptotic activity in many different types of cancer cells However, for a long time, the precise molecular target(s) of triptolide have remained elusive Recently, several groups discovered that triptolide inhibited the activity of RNA polymerase. This review will focus on these breakthrough findings about the molecular target of triptolide and its implications for targeted-cancer therapeutics. (C) 2009 Elseviei Ireland Ltd All rights reserved

引用

页码：149 / 152

页数：4

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