Atomic Force Microscopy Study on Chlorpromazine-Induced Morphological Changes of Living He La Cells In Vitro

被引：4

作者：

Li, Yongjun ^{[1
,2
]}

Zhang, Jing ^{[1
,2
]}

Zhang, Bailin ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanal Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

来源：

SCANNING | 2009年 / 31卷 / 06期

基金：

中国国家自然科学基金;

关键词：

atomic force microscopy; human cervical carcinoma cell; cell membrane; living cell; adhesion force; MEMBRANE;

D O I：

10.1002/sca.20174

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Chlorpromazine (CPZ)-induced morphological changes of living human cervical carcinoma cells were investigated by atomic force microscopy in near physiological condition. The results showed that the cell morphology changed visibly with time in the presence of CPZ (>21 mu M). The cell membrane shrank gradually and detached finally from the substrate. After being treated with CPZ for 50 min. the cell volume increased by about 27.6% while its projective area (cell adhered to the substrate) decreased by about 12%. The mechanism was also discussed. SCANNING 31: 259-265, 2009. (C) 2010 Wiley Periodicals, Inc.

引用

页码：259 / 265

页数：7

共 25 条

[1] A photometric method to analyze induced erythrocyte shape changes [J].