Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect

被引：89

作者：

Ivanova, Donika ^{[1
]}

Zhelev, Zhivko ^{[1
,2
]}

Getsov, Plamen ^{[3
]}

Nikolova, Biliana ^{[2
]}

Aoki, Ichio ^{[4
,5
]}

Higashi, Tatsuya ^{[4
]}

Bakalova, Rumiana ^{[4
,5
,6
]}

机构：

[1] Trakia Univ, Med Fac, Stara Zagora, Bulgaria

[2] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Sofia, Bulgaria

[3] Univ Hosp Tsaritsa Yoanna ISUL, Sofia, Bulgaria

[4] Natl Inst Quantum & Radiol Sci & Technol QST, NIRS, Dept Mol Imaging & Theranost, Chiba, Japan

[5] Natl Inst Quantum & Radiol Sci & Technol QST, NIRS, Quantum State Controlled MRI, Chiba, Japan

[6] Sofia Univ St Kliment Ohridski, Med Fac, Sofia, Bulgaria

来源：

REDOX BIOLOGY | 2018年 / 16卷

关键词：

MENADIONE-INDUCED CYTOTOXICITY; MATRIX GLA PROTEIN; OXIDATIVE STRESS; CANCER-CELLS; VASCULAR CALCIFICATION; DEPENDENT CARBOXYLATION; THERAPEUTIC APPROACH; ISOLATED HEPATOCYTES; GAMMA-CARBOXYLATION; GLIOMA-CELLS;

D O I：

10.1016/j.redox.2018.03.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of vitamin K and its effect on the calcium homeostasis, "oncogenic" and "onco-suppressive" reactive oxygen species and the specific induction of oxidative stress in cancer; (ii) vitamin K plus C as a powerful redox-system, which forms a bypass between mitochondrial complexes II and III and thus prevents mitochondrial dysfunction, restores oxidative phosphorylation and aerobic glycolysis, modulates the redox-state of endogenous redox-pairs, eliminates the hypoxic environment of cancer cells and induces cell death. The analyzed data suggest that vitamin C&K can sensitize cancer cells to conventional chemotherapy, which allows achievement of a lower effective dose of the drug and minimizing the harmful side-effects. The review is intended for a wide audience of readers - from students to specialists in the field.

引用

页码：352 / 358

页数：7

共 94 条

[1] Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by γ-carboxylation-dependent and -independent mechanisms [J].