Does the intensity of daily walking matter for protecting against the development of a slow gait speed in people with or at high risk of knee osteoarthritis? An observational study

被引：17

作者：

Fenton, S. A. M. ^{[1
,2
]}

Neogi, T. ^{[3
]}

Dunlop, D. ^{[4
]}

Nevitt, M. ^{[5
]}

Doherty, M. ^{[6
]}

Duda, J. L. ^{[1
]}

Klocke, R. ^{[2
]}

Abhishek, A. ^{[6
]}

Rushton, A. ^{[1
]}

Zhang, W. ^{[6
]}

Lewis, C. E. ^{[7
]}

Torner, J. ^{[8
]}

Kitas, G. ^{[1
,2
]}

White, D. K. ^{[9
]}

机构：

[1] Univ Birmingham, Sch Sport Exercise & Rehabil Sci, Birmingham, W Midlands, England

[2] Dudley Grp Hosp NHS Fdn Trust, Russells Hall Hosp, Dept Rheumatol, Dudley, England

[3] Boston Univ, Med Ctr, Clin Epidemiol Res & Training Unit, Boston, MA USA

[4] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

[5] Univ Calif San Francisco, San Francisco, CA 94143 USA

[6] Univ Nottingham, Fac Med & Hlth Sci, Nottingham, England

[7] Univ Alabama Birmingham, Birmingham, AL USA

[8] Univ Iowa, Iowa City, IA USA

[9] Univ Delaware, Dept Phys Therapy, Newark, DE USA

来源：

OSTEOARTHRITIS AND CARTILAGE | 2018年 / 26卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Knee osteoarthritis; Walking; Physical function; Gait speed; Accelerometry; Isotemporal substitution; PHYSICAL-ACTIVITY; MUSCLE MASS; OLDER PEDESTRIANS; SEDENTARY TIME; HEALTH; RELIABILITY; CADENCE; MONITOR; ADULTS; INTERVENTIONS;

D O I：

10.1016/j.joca.2018.04.015

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: Knee osteoarthritis (OA) is a risk factor for a decline in gait speed. Daily walking reduces the risk of developing slow gait speed and future persistent functional limitation. However, the protective role of walking intensity is unclear. We investigated the association of substituting time spent not walking, with walking at light and moderate-to-vigorous intensities for incident slow gait over 2-years, among people with or at high risk of knee OA. Method: We used baseline and 2-year follow-up data from the Multicenter Osteoarthritis (MOST) study (n = 1731) and the Osteoarthritis Initiative (OAI, n = 1925). Daily walking intensity was objectively assessed using accelerometer-enabled devices, and classified as; not walking (< 1 steps/min), very-light (1-49 steps/min), light (50-100 steps/min), and moderate-to-vigorous (> 100 steps/min). We defined slow gait during a 20-m walk, as < 1 m/s and < 1.2 m/s. Isotemporal substitution evaluated time-substitution effects on incident slow gait outcomes at 2-years. Results: Replacing 20 min/day of not walking with walking at a moderate-to-vigorous intensity, demonstrated small to moderate reductions in the risk of developing a gait speed < 1.0 m/s (Relative Risk [95% confidence interval (CI)]; MOST = 0.51 [0.27, 0.98], OAI = 0.21 [0.04, 0.98]), and < 1.2 m/s (MOST = 0.73 [0.53, 1.00], OAI = 0.65 [0.36, 1.18]). However, only risk reductions for < 1.0 m/s met statistical significance. Replacing not walking with very-light or light intensity walking was not associated with the risk of developing slow gait outcomes. Conclusion: When possible, walking at a moderate-to-vigorous intensity (> 100 steps/min) may be best recommended in order to reduce the risk of developing critical slow gait speed among people with, or at high risk of knee OA. (c) 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：1181 / 1189

页数：9

共 53 条

[1] Determination of Step Rate Thresholds Corresponding to Physical Activity Intensity Classifications in Adults [J].