Advanced Silk Fibroin Biomaterials for Cartilage Regeneration

被引：130

作者：

Cheng, Gu ^{[1
,2
,3
]}

Davoudi, Zahra ^{[4
]}

Xing, Xin ^{[1
,2
]}

Yu, Xin ^{[1
,2
]}

Cheng, Xin ^{[1
,2
]}

Li, Zubing ^{[1
,2
]}

Deng, Hongbing ^{[3
]}

Wang, Qun ^{[4
]}

机构：

[1] Wuhan Univ, Dept Oral & Maxillofacial Surg, Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan 430079, Hubei, Peoples R China

[2] Wuhan Univ, Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Hubei, Peoples R China

[3] Wuhan Univ, Sch Resource & Environm Sci, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Hubei, Peoples R China

[4] Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50014 USA

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2018年 / 4卷 / 08期

基金：

国家高技术研究发展计划(863计划);

关键词：

silk fibroin; cartilage regeneration; fabrication methods; scaffolds; MESENCHYMAL STEM-CELLS; TISSUE ENGINEERING APPLICATIONS; HYALURONIC-ACID HYDROGELS; IN-VITRO; DRUG-DELIVERY; CHONDROGENIC DIFFERENTIATION; BIOMEDICAL APPLICATIONS; ARTICULAR-CARTILAGE; CHONDROITIN SULFATE; POROUS SCAFFOLDS;

D O I：

10.1021/acsbiomaterials.8b00150

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Silk fibroin is regarded as a natural fibrous protein with tunable mechanical properties, acceptable biocompatibility, and favorable capability of enhancing attachment, proliferation, and differentiation of chondrocytes. These properties make it suitable for the fabrication of scaffolds and a broad range of silk fibroin-based biomaterials for cartilage regenerative therapy, which can heal functional cartilage without scar tissue. It can be used as a single material for making different kinds of scaffolds or as a composite with other types of biomaterials. Together with some growth factors, silk fibroin scaffolds can form a support for the growth and differentiation of seeding cells, such as chondrogenic lineage cells and mesenchymal stem cells. Recent advancements of silk fibroin in cartilage regeneration are summarized in this review. Furthermore, the manufacturing methods of silk fibroin materials and their applications in the regeneration of cartilage are also discussed.

引用

页码：2704 / 2715

页数：12

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