Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy

被引：229
作者：
Li, Jun [1 ]
Liang, Huamin [2 ]
Liu, Jing [3 ]
Wang, Ziyuan [1 ]
机构：
[1] Jiangsu Normal Univ, Sch Life Sci, Xuzhou 221116, Jiangsu, Peoples R China
[2] Chinese Acad Sci, Hefei Inst Phys Sci, Inst Technol Innovat, Hefei 230088, Anhui, Peoples R China
[3] Tsinghua Univ, Collaborat Innovat Ctr Biotherapy, Beijing 100084, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2018年 / 546卷 / 1-2期
关键词：
PAMAM dendrimer; Drug delivery; Gene therapy; Multidrug resistance; Hybrid nanoparticles; SURFACE-ENGINEERED DENDRIMERS; SELECTIVE SIRNA DELIVERY; POLYAMIDOAMINE DENDRIMER; IN-VITRO; MULTIDRUG-RESISTANCE; TARGETED DELIVERY; ANTICANCER DRUG; CELLULAR UPTAKE; GENE-THERAPY; POLY(AMIDOAMINE) DENDRIMERS;
D O I：
10.1016/j.ijpharm.2018.05.045
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poly (amidoamine) (PAMAM) dendrimers are well-defined, highly branched macromolecules with numerous active amine groups on the surface. Because of their unique properties, PAMAM dendrimers have steadily grown in popularity in drug delivery, gene therapy, medical imaging and diagnostic application. This review focuses on the recent developments on the application in PAMAM dendrimers as effective carriers for drug and gene (pDNA, siRNA) delivery in cancer therapy, including: a) PAMAM for anticancer drug delivery; b) PAMAM and gene therapy; c) PAMAM used in overcoming tumor multidrug resistance; d) PAMAM used for hybrid nanoparticles; and e) PAMAM linked or loaded in other nanoparticles.
引用
收藏
页码：215 / 225
页数：11
相关论文
共 137 条
[1]   Nanomedicine: An effective tool in cancer therapy [J].
Aftab, Saima ;
Shah, Afzal ;
Nadhman, Akhtar ;
Kurbanoglu, Sevinc ;
Ozkan, Sibel Aysil ;
Dionysiou, Dionysios D. ;
Shukla, Shyam S. ;
Aminabhavi, Tejraj M. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 540 (1-2) :132-149
[2]   Potential use of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate (G2) as a siRNA carrier for the treatment of familial amyloidotic polyneuropathy [J].
Anno, Takayuki ;
Higashi, Taishi ;
Hayashi, Yuya ;
Motoyama, Keiichi ;
Jono, Hirofumi ;
Ando, Yukio ;
Arima, Hidetoshi .
JOURNAL OF DRUG TARGETING, 2014, 22 (10) :883-890
[3]   Dipeptide-functionalized polyamidoamine dendrimer-mediated apoptin gene delivery facilitates apoptosis of human primary glioma cells [J].
Bae, Yoonhee ;
Green, Eric S. ;
Kim, Goo-Young ;
Song, Su Jeong ;
Mun, Ji Young ;
Lee, Sunray ;
Park, Jong-Il ;
Park, Jong-sang ;
Ko, Kyung Soo ;
Han, Jin ;
Choi, Joon Sig .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 515 (1-2) :186-200
[4]   Poly(amidoamine) (PAMAM): An emerging material for electrochemical bio(sensing) applications [J].
Bahadir, Elif Burcu ;
Sezginturk, Mustafa Kemal .
TALANTA, 2016, 148 :427-438
[5]   Polymeric nanoparticles: the future of nanomedicine [J].
Banik, Brittany L. ;
Fattahi, Pouria ;
Brown, Justin L. .
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2016, 8 (02) :271-299
[6]   Targeted nanomedicine for cancer therapeutics: Towards precision medicine overcoming drug resistance [J].
Bar-Zeev, Maya ;
Livney, Yoav D. ;
Assaraf, Yehuda G. .
DRUG RESISTANCE UPDATES, 2017, 31 :15-30
[7]   Association of Methotrexate with Native and PEGylated PAMAM-G4 Dendrimers: Effect of the PEGylation Degree on the Drug-Loading Capacity and Preferential Binding Sites [J].
Barraza, Luis F. ;
Jimenez, Veronica A. ;
Alderete, Joel B. .
JOURNAL OF PHYSICAL CHEMISTRY B, 2017, 121 (01) :4-12
[8]  
Beretta GL, 2016, CURR MED CHEM, V23, P3
[9]   A PEGylated dendritic nanoparticulate carrier of fluorouracil [J].
Bhadra, D ;
Bhadra, S ;
Jain, S ;
Jain, NK .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 257 (1-2) :111-124
[10]   TPP-dendrimer nanocarriers for siRNA delivery to the pulmonary epithelium and their dry powder and metered-dose inhaler formulations [J].
Bielski, Elizabeth ;
Zhong, Qian ;
Mirza, Hamad ;
Brown, Matthew ;
Molla, Ashura ;
Carvajal, Teresa ;
da Rocha, Sandro R. P. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 527 (1-2) :171-183
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