Changes in concentrations of tau-reactive antibodies are dependent on sex in Alzheimer's disease patients

The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: 1) against three various tau antigens 2) between AD patients, MCI and other dementias and cognitively normal individuals 3) to find out if the antibody levels are dependent on age and sex We observed higher reactivity of natural tau-reactive antibodies towards phosphorylated bovine tau protein than to human recombinant (non-phosphorylated) tau protein. Males with MCI-AD had higher amounts of these antibodies than corresponding controls. Concentrations of antibodies were lower in females with the MCI-AD than in control females. These findings may have implications for tau vaccination trials.