Pulmonary marginal zone B-cell lymphoma of MALT type-What is a prognostic factor and which is the optimal treatment, operation, or chemotherapy?: Consortium for Improving Survival of Lymphoma (CISL) Study

被引:51
作者
Oh, Sung Yong [1 ,14 ]
Kim, Won Seog [2 ]
Kim, Jin Seok [2 ]
Kim, Seok Jin [3 ]
Kwon, Hyuk-Chan [1 ,14 ]
Lee, Dae Ho [4 ]
Won, Jong Ho [5 ]
Hwang, In Gyu [6 ]
Kim, Min Kyoung [7 ]
Lee, Soon Il [8 ]
Chae, Yee Soo [9 ]
Yang, Deok-Hwan [10 ]
Lee, Gyeong-Won [11 ]
Choi, Chul Won [12 ]
Park, Jinny [13 ]
Suh, Cheolwon [4 ]
Kim, Hyo-Jin [1 ]
机构
[1] Dong A Univ, Dept Internal Med, Coll Med, Pusan 602715, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Hematol Oncol, Seoul, South Korea
[3] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[4] Univ Ulsan, Dept Internal Med, Coll Med, Asan Med Ctr, Seoul, South Korea
[5] Soon Chun Hyang Univ, Univ Coll Med, Dept Internal Med, Seoul, South Korea
[6] Chung Ang Univ, Div Hematol Oncol, Dept Med, Seoul 156756, South Korea
[7] Yeungnam Univ, Coll Med, Div Oncol, Dept Internal Med, Taegu, South Korea
[8] Dankook Univ, Dept Internal Med, Coll Med, Cheonan, South Korea
[9] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Taegu, South Korea
[10] Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Jeollanam Do, South Korea
[11] Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Div Hematol Oncol, Jinju, South Korea
[12] Korea Univ, Coll Med, Div Hematol Oncol, Dept Internal Med,Anam Hosp, Seoul 136705, South Korea
[13] Gachon Med Sch, Dept Internal Med, Inchon, South Korea
[14] Dong A Univ, Coll Med, Med Res Ctr Canc Mol Therapy, Pusan, South Korea
关键词
Pulmonary; Marginal zone; B-cell lymphoma; Chemotherapy; NON-HODGKINS-LYMPHOMA; TISSUE BALT; LUNG;
D O I
10.1007/s00277-009-0875-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pulmonary marginal zone B-cell lymphoma of the MALT type (P-MZL) is a relatively rare form of lymphoma. We conducted a retrospective analysis of the clinical features and treatment outcomes of P-MZL for the evaluation of prognostic factors, and to collect information about the optimal treatment modality for this condition. From 1991 to 2008, a total of 61 patients with biopsy-confirmed P-MZL were retrospectively analyzed. The median age of our subjects was 60 (range, 34-79) years. Twenty-five of the patients (41%) were initially diagnosed without any symptoms. Video-assisted thoracic surgery was utilized for diagnosis in 19 patients (31%). Thirty-eight patients' conditions (62%) involved a single lobe. Lung lesions were bilateral in 15 patients (25%). Eleven patients evidenced synchronous involvement of extra-pulmonary site MZL. Overall, 56 of 61 patients were treated with surgery (n = 22), chemotherapy (n = 28), or radiotherapy (n = 6). Among them, 46 patients achieved complete or partial remission. The median time to progression (TTP) was 5.6 (95% CI, 2.6-8.6) years. Five patients died during follow-up. Extra-pulmonary MZL and LN involvement were shown to be poor prognostic factors for TTP. We noted no differences between the operation group and chemotherapy group in terms of TTP. P-MZL tends to be an indolent disease-characterized by prolonged survival with frequent relapses. This is similar to what is observed with other cases of MALT-type site MZL. In order to conserve lung function and reduce the risks of operation, chemotherapy should be considered as a first-line option for the treatment of P-MZL.
引用
收藏
页码:563 / 568
页数:6
相关论文
共 17 条
[1]   Bronchial-associated lymphoid tissue lymphoma: a clinical study of a rare disease [J].
Ahmed, S ;
Kussick, SJ ;
Siddiqui, AK ;
Bhuiya, TA ;
Khan, A ;
Sarewitz, S ;
Steinberg, H ;
Sison, CP ;
Rai, KR .
EUROPEAN JOURNAL OF CANCER, 2004, 40 (09) :1320-1326
[2]   Low-grade B-Cell bronchial associated lymphoid tissue (BALT) lymphoma [J].
Ahmed, S ;
Siddiqui, AK ;
Rai, KR .
CANCER INVESTIGATION, 2002, 20 (7-8) :1059-1068
[3]   Marginal zone B-Cell lymphoma of bronchus-associated lymphoid tissue [J].
Bae, Young A. ;
Lee, Kyung Soo ;
Han, Joungho ;
Ko, Young-Hyeh ;
Kim, Byung-Tae ;
Chung, Myung Jin ;
Kim, Tae Sung .
CHEST, 2008, 133 (02) :433-440
[4]   Lymphoproliferative lung disorders [J].
Chilosi, M ;
Zinzani, PL ;
Poletti, V .
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 26 (05) :490-501
[5]   Primary non-Hodgkin's lymphoma of the lung [J].
Ferraro, P ;
Trastek, VF ;
Adlakha, H ;
Deschamps, C ;
Allen, MS ;
Pairolero, PC .
ANNALS OF THORACIC SURGERY, 2000, 69 (04) :993-997
[6]   Primary pulmonary lymphoma [J].
Graham, BB ;
Mathisen, DJ ;
Mark, EJ ;
Takvorian, RW .
ANNALS OF THORACIC SURGERY, 2005, 80 (04) :1248-1253
[7]   Primary pulmonary non-Hodgkin's lymphoma [J].
Kim, JH ;
Lee, SH ;
Park, J ;
Kim, HY ;
Lee, SI ;
Park, JO ;
Kim, K ;
Kim, WS ;
Jung, CW ;
Park, YS ;
Im, YH ;
Kang, WK ;
Lee, MH ;
Park, K ;
Han, JH ;
Ko, YH .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2004, 34 (09) :510-514
[8]   Nongastric marginal zone B-cell lymphoma: Analysis of 247 cases [J].
Oh, Sung Yong ;
Ryoo, Baek-Yeol ;
Kim, Won Seog ;
Park, Yeon Hee ;
Kim, Kihyun ;
Kim, Hyun Jung ;
Kwon, Jung Mi ;
Lee, Jeeyun ;
Ko, Young Hye ;
Ahn, Yong Chan ;
Oh, Suk Joong ;
Lee, Soon Il ;
Kim, Hyo-Jin ;
Kwon, Hyuk-Chan ;
Bang, Soo Mee ;
Kim, Jung Han ;
Park, Jinny ;
Lee, Seung-Sook ;
Kim, Ho Young ;
Park, Keunchil .
AMERICAN JOURNAL OF HEMATOLOGY, 2007, 82 (06) :446-452
[9]   IS THE BRONCHUS-ASSOCIATED LYMPHOID-TISSUE (BALT) AN INTEGRAL STRUCTURE OF THE LUNG IN NORMAL MAMMALS, INCLUDING HUMANS [J].
PABST, R ;
GEHRKE, I .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1990, 3 (02) :131-135
[10]   BRONCHUS-ASSOCIATED LYMPHOID-TISSUE (BALT) IN HUMAN LUNG - ITS DISTRIBUTION IN SMOKERS AND NONSMOKERS [J].
RICHMOND, I ;
PRITCHARD, GE ;
ASHCROFT, T ;
AVERY, A ;
CORRIS, PA ;
WALTERS, EH .
THORAX, 1993, 48 (11) :1130-1134