Low Intensity Pulsed Ultrasound for Bone Augmentation A Synchrotron Radiation X-Ray micro-CT evaluation

Low-intensity pulsed ultrasound (LIPUS) exposure was used as a treatment procedure for healing the fractures in case of animals and clinical studies. The healing period of time is shorter for this method and the healing rate is considerably reduced. In this study were used rats on which was made bone augmentation. The augmentation materials were implanted in the medullar cavity of femur. The interested area was X-ray evaluated for 12 weeks. After 84 days the rats were euthanasia and the bone area treated through augmentation was exarticulated and investigated with synchrotron radiation X-Ray micro-CT The scans were processed with a designed software and the images became 3D reconstructions. The samples where the Low Intensity Pulsed Ultrasound was used for Bone Augmentation revealed a good quantity and quality of a new bone formation in the area of the induced defect. An accurate analyze evaluated the method of augmentation procedure. The specific mechanism by which low intensity pulsed ultrasound technology accelerate bone healing remains unknown. In terms of the physical mechanism, this technology may exert a mechanical force on cell in soft tissue at the fracture gap. Evaluation of the bone grafting material/bone interface with noninvasive methods such as microCT using the synchrotron radiation could act as a valuable procedure that can be used in the future for usual research procedures.