NSAIDs in dermatologic therapy: Review and preview

被引:42
作者
Friedman, ES [1 ]
LaNatra, N [1 ]
Stiller, MJ [1 ]
机构
[1] Columbia Presbyterian Med Ctr, Clin Pharmacol Unit, Dept Dermatol, New York, NY 10032 USA
关键词
D O I
10.1007/s10227-001-0137-3
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been an important therapy in the treatment of a large number of cutaneous pathologies for more than three decades. Objective: In this retrospective review, we document the use of NSAIDs in more than 15 common and uncommon dermatoses, including acne, psoriasis, sunburn, erythema nodosum, cryoglobulinemia, Sweet's syndrome, systemic mastocytosis, as well as urticarial, livedoid, and nodular vasculitis. NSAIDs act mainly by inhibiting prostaglandin synthesis by the cyclooxygenase (COX) pathway. Conclusion: Recent studies link prostaglandin to cutaneous carcinogenesis, thus expanding the dermatologic use of NSAIDs. They may be effective in the treatment and prevention of non-melanoma skin cancer, and specific COX-2 inhibitors promise safer, broader, long-term use of these pharmacologically innovative drugs.
引用
收藏
页码:449 / 459
页数:11
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