Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides

被引:57
作者
Dharmaratne, Nayanthara U. [1 ]
Kaplan, Alanna R. [1 ]
Glazer, Peter M. [1 ,2 ]
机构
[1] Yale Univ, Dept Therapeut Radiol, New Haven, CT 06520 USA
[2] Yale Univ, Dept Genet, New Haven, CT 06520 USA
关键词
hypoxia; acidity; pHLIP; tumor targeting; peptide nucleic acids; toxins; nanoparticles; imaging;
D O I
10.3390/cells10030541
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The delivery of cancer therapeutics can be limited by pharmacological issues such as poor bioavailability and high toxicity to healthy tissue. pH-low insertion peptides (pHLIPs) represent a promising tool to overcome these limitations. pHLIPs allow for the selective delivery of agents to tumors on the basis of pH, taking advantage of the acidity of the hypoxic tumor microenvironment. This review article highlights the various applications in which pHLIPs have been utilized for targeting and treating diseases in hypoxic environments, including delivery of small molecule inhibitors, toxins, nucleic acid analogs, fluorescent dyes, and nanoparticles.
引用
收藏
页码:1 / 14
页数:14
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