The delivery of cancer therapeutics can be limited by pharmacological issues such as poor bioavailability and high toxicity to healthy tissue. pH-low insertion peptides (pHLIPs) represent a promising tool to overcome these limitations. pHLIPs allow for the selective delivery of agents to tumors on the basis of pH, taking advantage of the acidity of the hypoxic tumor microenvironment. This review article highlights the various applications in which pHLIPs have been utilized for targeting and treating diseases in hypoxic environments, including delivery of small molecule inhibitors, toxins, nucleic acid analogs, fluorescent dyes, and nanoparticles.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Adochite, Ramona-Cosmina
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Moshnikova, Anna
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Moshnikova, Anna
;
Carlin, Sean D.
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Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Carlin, Sean D.
;
Guerrieri, Renato A.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Guerrieri, Renato A.
;
Andreev, Oleg A.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Andreev, Oleg A.
;
Lewis, Jason S.
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Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Program Mol Pharmacol & Chem, New York, NY 10065 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Lewis, Jason S.
;
Reshetnyak, Yana K.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
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Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Brown Univ, Dept Phys, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Antosh, Michael P.
;
Wijesinghe, Dayanjali D.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Wijesinghe, Dayanjali D.
;
Shrestha, Samana
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Shrestha, Samana
;
Lanou, Robert
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Brown Univ, Dept Phys, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Lanou, Robert
;
Huang, Yun Hu
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Brown Univ, Dept Phys, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Huang, Yun Hu
;
Hasselbacher, Thomas
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Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Hasselbacher, Thomas
;
Fox, David
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Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Fox, David
;
Neretti, Nicola
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Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Neretti, Nicola
;
Sun, Shouheng
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Brown Univ, Dept Chem, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Sun, Shouheng
;
Katenka, Natallia
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Univ Rhode Isl, Dept Comp Sci & Stat, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Katenka, Natallia
;
Cooper, Leon N.
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Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Brown Univ, Dept Phys, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Cooper, Leon N.
;
Andreev, Oleg A.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Andreev, Oleg A.
;
Reshetnyak, Yana K.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Adochite, Ramona-Cosmina
;
Moshnikova, Anna
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Moshnikova, Anna
;
Carlin, Sean D.
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h-index: 0
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Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Carlin, Sean D.
;
Guerrieri, Renato A.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Guerrieri, Renato A.
;
Andreev, Oleg A.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Andreev, Oleg A.
;
Lewis, Jason S.
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Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Program Mol Pharmacol & Chem, New York, NY 10065 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
Lewis, Jason S.
;
Reshetnyak, Yana K.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USAUniv Rhode Isl, Dept Phys, Kingston, RI 02881 USA
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Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Brown Univ, Dept Phys, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Antosh, Michael P.
;
Wijesinghe, Dayanjali D.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Wijesinghe, Dayanjali D.
;
Shrestha, Samana
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Shrestha, Samana
;
Lanou, Robert
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Brown Univ, Dept Phys, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Lanou, Robert
;
Huang, Yun Hu
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Brown Univ, Dept Phys, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Huang, Yun Hu
;
Hasselbacher, Thomas
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Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Hasselbacher, Thomas
;
Fox, David
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Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Fox, David
;
Neretti, Nicola
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Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Neretti, Nicola
;
Sun, Shouheng
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Brown Univ, Dept Chem, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Sun, Shouheng
;
Katenka, Natallia
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Univ Rhode Isl, Dept Comp Sci & Stat, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Katenka, Natallia
;
Cooper, Leon N.
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机构:
Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Brown Univ, Dept Phys, Providence, RI 02912 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Cooper, Leon N.
;
Andreev, Oleg A.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA
Andreev, Oleg A.
;
Reshetnyak, Yana K.
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Univ Rhode Isl, Dept Phys, Kingston, RI 02881 USABrown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA