In vitro and in vivo cytocompatibility evaluation of biodegradable magnesium-based stents: a review

被引：30

作者：

Li, Ping ^{[1
]}

Zhou, Ningling ^{[1
]}

Qiu, Hua ^{[1
]}

Maitz, Manfred F. ^{[1
,2
]}

Wang, Juan ^{[1
,3
]}

Huang, Nan ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China

[2] Max Bergmann Ctr Biomat Dresden, Leibniz Inst Polymer Res Dresden, D-01069 Dresden, Germany

[3] Yale Univ, Sch Med, Dept Anesthesiol, 333 Cedar St, New Haven, CT 06511 USA

来源：

SCIENCE CHINA-MATERIALS | 2018年 / 61卷 / 04期

基金：

中国国家自然科学基金;

关键词：

magnesium; stent; cytocompatibility; in vitro; in vivo; OPTICAL COHERENCE TOMOGRAPHY; HUMAN ENDOTHELIAL-CELLS; INTRAVASCULAR ULTRASOUND; CORROSION-RESISTANCE; ALLOY STENTS; METAL STENT; INFLAMMATORY RESPONSE; MECHANICAL-PROPERTIES; BIOABSORBABLE STENTS; CORONARY-ARTERIES;

D O I：

10.1007/s40843-017-9194-y

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Biodegradable magnesium (Mg)-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow. Numerous studies have presented in vitro and in vivo tests for the evaluation of the safety and feasibility of Mg-based vascular stents and the related materials. Therein the cyto-compatibility is a basic and important parameter in the evaluation system. In this review, we summarize the applications and limitations of in vitro evaluation methods including basic characterization methods and direct and indirect cytotoxicity tests. We discuss the influencing factors on cytotoxicity, such as surface roughness, preconditioning of sample surface, cell type for the biocompatibility evaluation in direct contact as well as conditions for the formation of extracts/degradation products for indirect assays. Besides, we highlight the recent in vivo animal tests and clinical trials about Mg-based stents along with some associated results. The aim of this review is to provide a meaningful reference in the further developments and related evaluation methods of Mg-based stents.

引用

页码：501 / 515

页数：15

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