Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method

被引：28
|
作者：
Li, Changqin [1 ,2 ,3 ]
Cui, Yiping [1 ,2 ]
Lu, Jie [1 ]
Meng, Lijun [1 ]
Ma, Changyang [1 ,2 ,3 ]
Liu, Zhenhua [1 ,2 ,3 ]
Zhang, Yan [4 ]
Kang, Wenyi [1 ,2 ,3 ]
机构：
[1] Henan Univ, Natl R&D Ctr Edible Fungus Proc Technol, Kaifeng 475004, Peoples R China
[2] Funct Food Engn Technol Res Ctr, Kaifeng 475004, Henan, Peoples R China
[3] Henan Univ, Joint Int Res Lab Food & Med Resource Funct, Kaifeng 475004, Henan, Peoples R China
[4] Hebei Food Inspect & Res Inst, Shijiazhuang 050091, Hebei, Peoples R China
来源：
FOOD SCIENCE AND HUMAN WELLNESS | 2021年 / 10卷 / 03期
基金：
国家重点研发计划;
关键词：
Ganoderma lucidum; RAW; 264.7; cell; Spectrum-effect relationships; Component knock-out; BP neural network; REISHI MEDICINAL MUSHROOM; LINGZHI; TRITERPENOIDS; ANTIOXIDANT; APOPTOSIS; SYSTEM; KARST;
D O I：
10.1016/j.fshw.2021.02.019
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This study was designed to elucidate the immunoregulation of Ganoderma lucidum. HPLC fingerprint and spectrum-effect relationship of G. lucidum were established to predict the active compounds and BP neural network model was established to predict the efficacy. Then the target compounds were identified by high resolution mass spectrometry. The results indicated that there are both enhanced immunity and immunosuppressive components in G. lucidum. BP neural network was trained with the common peak area G. lucidum G. lucidum R of BP network model was 0.986 43, by high resolution mass spectrometry. The compounds related to immune activity in G. lucidum were determined in this study. (C) 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
引用
收藏
页码：278 / 288
页数：11
相关论文
共 50 条
  • [21] Effect of Baicalein on the Pharmacokinetics of Cilostazol and Its Two Metabolites in Rat Plasma Using UPLC-MS/MS Method
    Weng, Qinghua
    Chen, Chaojie
    Xiong, Jianhua
    Liu, Ya-Nan
    Pan, Xinxin
    Cui, Ju
    Cai, Jian-Ping
    Xu, Ren-Ai
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [22] UPLC-MS-based serum metabolomics reveals protective effect of Ganoderma lucidum polysaccharide on ionizing radiation injury
    Yu, Chunmiao
    Fu, Jiaqi
    Guo, Lidong
    Lian, Lian
    Yu, Donghua
    JOURNAL OF ETHNOPHARMACOLOGY, 2020, 258
  • [23] An UPLC-MS/MS Method for Highly Selective and Sensitive Determination of Jiangxienone from Cordyceps jiangxiensis with Potent Antitumor Activity
    Liu, Yuan-Yuan
    Zhong, Jian-Jiang
    Xiao, Jian-Hui
    LATIN AMERICAN JOURNAL OF PHARMACY, 2016, 35 (02): : 265 - 273
  • [24] Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect
    Xu, Yuxiang
    Gao, Xiaonan
    Zhu, Yunfang
    Zhang, Qi
    Qie, Hongxin
    Zhao, Haopeng
    Gao, Jinglin
    Wang, Mingxia
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2023, 17 : 3551 - 3561
  • [25] Screening anti-fatigue components of American ginseng saponin by analyzing spectrum-effect relationship coupled with UPLC-Q-TOF-MS
    Lin, Meiyu
    Hu, Shaiping
    Zeng, Qi
    Xiao, Bixia
    He, Yao
    ASIAN BIOMEDICINE, 2023, 17 (04) : 163 - 172
  • [26] Screening and identification of hepatotoxic component in Evodia rutaecarpa based on spectrum-effect relationship and UPLC-Q-TOFMS
    Li, Wenlan
    Sun, Xiangming
    Liu, Bingmei
    Zhang, Lihui
    Fan, Ziquan
    Ji, Yubin
    BIOMEDICAL CHROMATOGRAPHY, 2016, 30 (12) : 1975 - 1983
  • [27] Effect on hypoglycemic activity and UPLC-MS/MS profiling of Rosa roxburghii fruit fermented with Chinese traditional distiller's yeast
    Yan, Yanfang
    Luo, Zhongsheng
    Deng, Tingfei
    Cui, Xiaofang
    Yang, Juan
    Pan, Xiong
    Yang, Lishou
    Wang, Yu
    Li, Liangqun
    Li, Lilang
    Gao, Ming
    Yang, Xiaosheng
    FOOD SCIENCE AND TECHNOLOGY, 2022, 42
  • [28] Screening of analgesic and anti-inflammatory active component in Fructus Alpiniae zerumbet based on spectrum-effect relationship and GC-MS
    Xiao, Rui-Yao
    Wu, Ling-Jing
    Hong, Xiao-Xiao
    Tao, Ling
    Luo, Peng
    Shen, Xiang-Chun
    BIOMEDICAL CHROMATOGRAPHY, 2018, 32 (03)
  • [29] Evaluation of cellular antioxidant components of honeys using UPLC-MS/MS and HPLC-FLD based on the quantitative composition-activity relationship
    Shen, Shi
    Wang, Jingbo
    Chen, Xi
    Liu, Tingting
    Zhuo, Qin
    Zhang, Shuang-Qing
    FOOD CHEMISTRY, 2019, 293 : 169 - 177
  • [30] Spectrum-effect relationship between UPLC-Q-TOF-MS fingerprint and anti-AUB effect of Clinopodium chinense (Benth.) O. Kuntze
    Qi, Jiajia
    Zhang, Qianqian
    Li, Lili
    Huang, Qi
    Yao, Min
    Wang, Ning
    Peng, Daiyin
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 217
12345