Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method

被引：28
|
作者：
Li, Changqin [1 ,2 ,3 ]
Cui, Yiping [1 ,2 ]
Lu, Jie [1 ]
Meng, Lijun [1 ]
Ma, Changyang [1 ,2 ,3 ]
Liu, Zhenhua [1 ,2 ,3 ]
Zhang, Yan [4 ]
Kang, Wenyi [1 ,2 ,3 ]
机构：
[1] Henan Univ, Natl R&D Ctr Edible Fungus Proc Technol, Kaifeng 475004, Peoples R China
[2] Funct Food Engn Technol Res Ctr, Kaifeng 475004, Henan, Peoples R China
[3] Henan Univ, Joint Int Res Lab Food & Med Resource Funct, Kaifeng 475004, Henan, Peoples R China
[4] Hebei Food Inspect & Res Inst, Shijiazhuang 050091, Hebei, Peoples R China
来源：
FOOD SCIENCE AND HUMAN WELLNESS | 2021年 / 10卷 / 03期
基金：
国家重点研发计划;
关键词：
Ganoderma lucidum; RAW; 264.7; cell; Spectrum-effect relationships; Component knock-out; BP neural network; REISHI MEDICINAL MUSHROOM; LINGZHI; TRITERPENOIDS; ANTIOXIDANT; APOPTOSIS; SYSTEM; KARST;
D O I：
10.1016/j.fshw.2021.02.019
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This study was designed to elucidate the immunoregulation of Ganoderma lucidum. HPLC fingerprint and spectrum-effect relationship of G. lucidum were established to predict the active compounds and BP neural network model was established to predict the efficacy. Then the target compounds were identified by high resolution mass spectrometry. The results indicated that there are both enhanced immunity and immunosuppressive components in G. lucidum. BP neural network was trained with the common peak area G. lucidum G. lucidum R of BP network model was 0.986 43, by high resolution mass spectrometry. The compounds related to immune activity in G. lucidum were determined in this study. (C) 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
引用
收藏
页码：278 / 288
页数：11
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