Prediction of drug solubility in ternary solvent mixture

被引：20

作者：

Jouyban-Gharamaleki, A

Clark, BJ

Acree, WE ^{[1
]}

机构：

[1] Univ N Texas, Dept Chem, Denton, TX 76203 USA

[2] Univ Bradford, Sch Pharm, Drug Design Grp, Bradford BD7 1DP, W Yorkshire, England

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2000年 / 26卷 / 09期

关键词：

drug solubility; solubility prediction; ternary solvent mixtures;

D O I：

10.1081/DDC-100101324

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Applicability of the combined, nearly ideal, binary solvent/Redlich-Kister equation for calculating drug solubility in ternary mixtures is presented The advantages of the proposed model are discussed and compared with a recently published equation that calculates the solute solubility in ternary solvent mixtures based on the mixture response methodology.

引用

页码：971 / 973

页数：3

共 8 条

[1] MATHEMATICAL REPRESENTATION OF THERMODYNAMIC PROPERTIES .2. DERIVATION OF THE COMBINED NEARLY IDEAL BINARY SOLVENT (NIBS) REDLICH-KISTER MATHEMATICAL REPRESENTATION FROM A 2-BODY AND 3-BODY INTERACTIONAL MIXING MODEL [J].