Innate and adaptive immunity in atherosclerosis

被引：46

作者：

Miteva, Kapka ^{[1
]}

Madonna, Rosalinda ^{[2
]}

De Caterina, Raffaele ^{[2
]}

Van Linthout, Sophie ^{[3
,4
,5
]}

机构：

[1] Humanitas Clin & Res Ctr, Adapt Immun Lab, Dept Biomed Sci, Milan, Italy

[2] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Inst Cardiol, Ctr Aging Sci & Translat Med CESI MeT, Chieti, Italy

[3] Charite Univ Med Berlin, Berlin Brandenburg Ctr Regenerat Therapies, Campus Virchow Klinikum, Berlin, Germany

[4] Charite Univ Med Berlin, Dept Cardiol, Campus Virchow Klinikum, Berlin, Germany

[5] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany

来源：

VASCULAR PHARMACOLOGY | 2018年 / 107卷

关键词：

Atherosclerosis; Sterile inflammation; Damage-associated molecular patterns; NLRP3; inflammasome; Immune cells; NEUTROPHIL EXTRACELLULAR TRAPS; SMOOTH-MUSCLE-CELLS; REGULATORY T-CELLS; PROMOTES VASCULAR INFLAMMATION; MYOCARDIAL-INFARCTION; MACROPHAGE IMMUNOMETABOLISM; REDUCES ATHEROSCLEROSIS; NLRP3; INFLAMMASOMES; CHEMOKINE RECEPTOR; INTERFERON-GAMMA;

D O I：

10.1016/j.vph.2018.04.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atherosclerosis is a chronic inflammatory disorder of the large and medium-size arteries characterized by the subendothelial accumulation of cholesterol, immune cells, and extracellular matrix. At the early onset of atherogenesis, endothelial dysfunction takes place. Atherogenesis is further triggered by the accumulation of cholesterol-carrying low-density lipoproteins, which acquire properties of damage-associated molecular patterns and thereby trigger an inflammatory response. Following activation of the innate immune response, mainly governed by monocytes and macrophages, the adaptive immune response is started which further promotes atherosclerotic plaque formation. In this review, an overview is given describing the role of damage-associated molecular patterns, NLRP3 inflammasome activation, and innate and adaptive immune cells in the atherogenesis process.

引用

页码：67 / 77

页数：11