SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients

被引：10

作者：

Hussein, Usama Khamis ^{[1
,2
,3
]}

Ahmed, Asmaa Gamal ^{[1
,4
]}

Choi, Won Ku ^{[2
,5
]}

Kim, Kyoung Min ^{[1
,2
]}

Park, See-Hyoung ^{[6
]}

Park, Ho Sung ^{[1
,2
]}

Noh, Sang Jae ^{[7
]}

Lee, Ho ^{[7
]}

Chung, Myoung Ja ^{[1
,2
]}

Moon, Woo Sung ^{[1
,2
]}

Kang, Myoung Jae ^{[1
,2
]}

Cho, Dong Hyu ^{[2
,5
]}

Jang, Kyu Yun ^{[1
,2
]}

机构：

[1] Jeonbuk Natl Univ, Med Sch, Dept Pathol, Jeonju 54896, South Korea

[2] Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Biomed Res Inst, Res Inst Clin Med, Jeonju 54907, South Korea

[3] Beni Suef Univ, Fac Sci, Bani Suwayf 62511, Egypt

[4] Beni Suef Univ, Fac Postgrad Studies Adv Sci, Bani Suwayf 62511, Egypt

[5] Jeonbuk Natl Univ, Med Sch, Dept Obstet & Gynecol, Jeonju 54896, South Korea

[6] Hongik Univ, Dept Bio & Chem Engn, Sejong 30016, South Korea

[7] Jeonbuk Natl Univ, Med Sch, Dept Forens Med, Jeonju 54896, South Korea

来源：

BIOMOLECULES | 2021年 / 11卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

ovary; cancer; SCRIB; epithelial-to-mesenchymal transition; prognosis; PROMOTES MAMMARY TUMORIGENESIS; BREAST-CANCER; CELL POLARITY; FAM83H; EXPRESSION; CATENIN; EMT;

D O I：

10.3390/biom11030405

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SCRIB is a polarity protein important in maintaining cell junctions. However, recent reports have raised the possibility that SCRIB might have a role in human cancers. Thus, this study evaluated the roles of SCRIB in ovarian cancers. In 102 human ovarian carcinomas, nuclear expression of SCRIB predicted shorter survival of ovarian carcinoma patients, especially in the patients who received post-operative chemotherapy. In SKOV3 and SNU119 ovarian cancer cells, overexpression of SCRIB stimulated the proliferation and invasion of cells. Knockout of SCRIB inhibited in vivo tumor growth of SKOV3 cells and overexpression of SCRIB promoted tumor growth. Overexpression of SCRIB stimulated epithelial-to-mesenchymal transition by increasing the expression of N-cadherin, snail, TGF-beta 1, and smad2/3, and decreasing the expression of E-cadherin; the converse was observed with inhibition of SCRIB. In conclusion, this study presents the nuclear expression of SCRIB as a prognostic marker of ovarian carcinomas and suggests that SCRIB is involved in the progression of ovarian carcinomas by stimulating proliferation and epithelial-to-mesenchymal transition-related invasiveness.

引用

页码：1 / 18

页数：18

共 38 条

[1] Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma [J].