Inversion-based propofol dosing for intravenous induction of hypnosis

被引：45

作者：

Padula, F. ^{[1
]}

Ionescu, C. ^{[2
]}

Latronico, N. ^{[3
,4
]}

Paltenghi, M. ^{[4
]}

Visioli, A. ^{[5
]}

Vivacqua, G. ^{[5
]}

机构：

[1] Univ Brescia, Dept Informat Engn, I-25121 Brescia, Italy

[2] Univ Ghent, Dept Elect Energy Syst & Automat, B-9000 Ghent, Belgium

[3] Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, I-25121 Brescia, Italy

[4] Spedali Civili Univ Hosp, Dept Anesthesiol Crit Care & Emergency, Brescia, Italy

[5] Univ Brescia, Dipartimento Ingn Meccan & Ind, I-25121 Brescia, Italy

来源：

COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION | 2016年 / 39卷

关键词：

Depth of hypnosis control; Feedforward control; Input-output inversion; CLOSED-LOOP CONTROL; SET-POINT REGULATION; BISPECTRAL INDEX; PERFORMANCE ASSESSMENT; CLINICAL-EVALUATION; ANESTHESIA; SYSTEM; DEPTH; TITRATION; DELIVERY;

D O I：

10.1016/j.cnsns.2016.04.003

中图分类号：

O29 [应用数学];

学科分类号：

070104 ;

摘要：

In this paper we propose an inversion-based methodology for the computation of a feedforward action for the propofol intravenous administration during the induction of hypnosis in general anesthesia. In particular, the typical initial bolus is substituted with a command signal that is obtained by predefining a desired output and by applying an input-output inversion procedure. The robustness of the method has been tested by considering a set of patients with different model parameters, which is representative of a large population. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：481 / 494

页数：14

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