Stable pyrano[2,3-b]quinoxalines and pyrano[2,3-g]pteridines related to molybdopterin

被引：30

作者：

Bradshaw, B ^{[1
]}

Collison, D ^{[1
]}

Garner, CD ^{[1
]}

Joule, JA ^{[1
]}

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 01期

关键词：

D O I：

10.1039/b008544h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The syntheses of the quinoxaline and pteridine proligands (3 and 4) related to molybdopterin are described and 3 has been characterised complexed via its dithiolene group to a CpCo(iii) centre (5). Each of 3-5 has the sensitive hemiaminal unit of molybdopterin, unprotected, verifying its stability in vitro.

引用

页码：123 / 124

页数：2

共 21 条

[1] Crystal structure of formate dehydrogenase H: Catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster [J].

Boyington, JC ;

Gladyshev, VN ;

Khangulov, SV ;

Stadtman, TC ;

Sun, PD .

SCIENCE, 1997, 275 (5304) :1305-1308

[2] Synthesis of a cobalt complex of a pyrano[2,3-b]quinoxaline-3,4-dithiolate related to molybdopterin [J].

Bradshaw, B ;

Dinsmore, A ;

Garner, CD ;

Joule, JA .

CHEMICAL COMMUNICATIONS, 1998, (03) :417-418

[3] STRUCTURE OF A HYPERTHERMOPHILIC TUNGSTOPTERIN ENZYME, ALDEHYDE FERREDOXIN OXIDOREDUCTASE [J].

CHAN, MK ;

MUKUND, S ;

KLETZIN, A ;

ADAMS, MWW ;

REES, DC .

SCIENCE, 1995, 267 (5203) :1463-1469

[4] Crystal structure of oxidized trimethylamine N-oxide reductase from Shewanella massilia at 2.5 Å resolution [J].

Czjzek, M ;

Dos Santos, JP ;

Pommier, J ;

Giordano, G ;

Méjean, V ;

Haser, R .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 284 (02) :435-447

[5] Crystal structure of the first dissimilatory nitrate reductase at 1.9 Å solved by MAD methods [J].

Dias, JM ;

Than, ME ;

Humm, A ;

Huber, R ;

Bourenkov, GP ;

Bartunik, HD ;

Bursakov, S ;

Calvete, J ;

Caldeira, J ;

Carneiro, C ;

Moura, JJG ;

Moura, I ;

Romao, MJ .

STRUCTURE, 1999, 7 (01) :65-79

[6] 4-(2,2-dimethyldioxalan-4-yl)-5-(pterin-6-yl)-1,3-dithiol-2-ones proligands relating to the cofactor of the oxomolybdoenzymes [J].

Dinsmore, A ;

Garner, CD ;

Joule, JA .

TETRAHEDRON, 1998, 54 (33) :9559-9568

[7] 4-(2,2-dimethyldioxalan-4-yl)-5-(quinoxalin-2-yl)-1,3-dithiol-2-one, a proligand relating to the cofactor of the oxomolybdoenzymes [J].

Dinsmore, A ;

Garner, CD ;

Joule, JA .

TETRAHEDRON, 1998, 54 (13) :3291-3302

[8] Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine [J].

Dobbek, H ;

Gremer, L ;

Meyer, O ;

Huber, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :8884-8889

[9] Site-directed mutagenesis of recombinant sulfite oxidase - Identification of cysteine 207 as a ligand of molybdenum [J].

Garrett, RM ;

Rajagopalan, KV .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) :7387-7391

[10] The relative stabilities of dihydropterins; a comment on the structure of Moco, the cofactor of the oxomolybdoenzymes [J].

Greatbanks, SP ;

Hillier, IH ;

Garner, CD ;

Joule, JA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1997, (08) :1529-1534

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