Chitin nanofibrils suppress skin inflammation in atopic dermatitis-like skin lesions in NC/Nga mice

被引：26

作者：

Izumi, Ryotaro ^{[1
]}

Azuma, Kazuo ^{[2
]}

Izawa, Hironori ^{[1
]}

Morimoto, Minoru ^{[3
]}

Nagashima, Masaaki ^{[4
]}

Osaki, Tomohiro ^{[2
]}

Tsuka, Takeshi ^{[2
]}

Imagawa, Tomohiro ^{[2
]}

Ito, Norihiko ^{[2
]}

Okamoto, Yoshiharu ^{[2
]}

Saimoto, Hiroyuki ^{[1
]}

Ifuku, Shinsuke ^{[1
]}

机构：

[1] Tottori Univ, Grad Sch Engn, Tottori 6808533, Japan

[2] Tottori Univ, Dept Vet Clin Med, Tottori 6808533, Japan

[3] Tottori Univ, Res Ctr Biosci & Technol, Div Instrumental Anal, Tottori 6808550, Japan

[4] Tottori Univ, Reg Ind Acad Cooperat, Tottori 6800833, Japan

来源：

CARBOHYDRATE POLYMERS | 2016年 / 146卷

关键词：

Chitin nanofibril; Atopic dermatitis; Corticosteroids; Nuclear factor-kappa B; Cyclooxygenase-2; Inducible nitric oxide synthase; NF-KAPPA-B; ALPHA-CHITIN; INHIBITOR; DISEASE; ECZEMA; MECHANISMS; MODELS; WIDTH;

D O I：

10.1016/j.carbpol.2016.03.068

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We evaluated the effect of chitin nanofibril (CNF) application via skin swabs on an experimental atopic dermatitis (AD) model. AD scores were lower, and hypertrophy and hyperkeratosis of the epidermis were suppressed after CNF treatment. Furthermore, inflammatory cell infiltration in both the epidermis and dermis was inhibited. CNFs also attenuated histological scores. The suppressive effects of CNFs were equal to those of corticosteroid application; however, chitin did not show these effects. CNF application might have antiinfllammatory effects via suppression of the activation of nuclear factor -kappa B, cyclooxygenase-2, and inducible nitric oxide synthase. In an early-stage model of experimental AD, CNFs suppressed AD progression to the same extent as corticosteroids. They also suppressed skin inflammation and IgE serum levels. Our findings indicate that CNF application could aid in the prevention or treatment of AD skin lesions. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：320 / 327

页数：8

共 43 条

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