A Novel Cylinder-Type Poly(L-Lactic Acid)-Collagen Hybrid Sponge for Cartilage Tissue Engineering

被引：0

作者：

He, Xiaoming ^{[1
]}

Lu, Hongxu ^{[1
]}

Kawazoe, Naoki ^{[1
]}

Tateishi, Tetsuya ^{[1
]}

Chen, Guoping ^{[1
]}

机构：

[1] Natl Inst Mat Sci, Biomat Ctr, Tsukuba, Ibaraki 3050044, Japan

来源：

TISSUE ENGINEERING PART C-METHODS | 2010年 / 16卷 / 03期

关键词：

MESENCHYMAL STEM-CELLS; MARROW STROMAL CELLS; COMPOSITE SCAFFOLDS; COLLAGEN SCAFFOLDS; IN-VITRO; INJECTABLE SCAFFOLD; ACID) MICROSPHERES; DIFFERENTIATION; POROSITY; CULTURE;

D O I：

10.1089/ten.tec.2008.0703

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The development of porous scaffolds having both high porosity and strong mechanical strength for tissue engineering and regenerative medicine has been quite challenging. A novel hybrid poly(L-lactic acid) (PLLA) collagen hybrid sponge was developed by enclosing collagen sponge in a cup-shaped PLLA sponge to meet the necessary requirements. Collagen sponge was formed in the center of the PLLA sponge cup, and collagen microsponges were formed in the pores of the PLLA sponge cup. The PLLA-collagen hybrid sponge showed higher mechanical strength than did those of the PLLA sponge cup and collagen sponge. The porosity of the PLLA-collagen hybrid sponge was greater than that of the PLLA sponge cup. The cup-shaped PLLA sponge skeleton provided the hybrid sponge with high mechanical strength and protected against cell leakage during cell seeding, while the central collagen sponge contributed to high porosity, and facilitated cell adhesion and distribution in the hybrid sponge. Cartilaginous tissue was successfully regenerated when chondrocytes were cultured in the hybrid sponge. This method of hybridization will provide a new technique for the preparation of functional porous scaffolds for tissue engineering.

引用

页码：329 / 338

页数：10

共 40 条

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