The synthesis and anti-inflammatory activity of quinopimaric acid derivatives

被引：27

作者：

Kazakova, O. B. ^{[1
]}

Tret'yakova, E. V. ^{[1
]}

Smirnova, I. E. ^{[1
]}

Spirikhin, L. V. ^{[1
]}

Tolstikov, G. A. ^{[1
]}

Chudov, I. V. ^{[2
]}

Bazekin, G. V. ^{[2
]}

Ismagilova, A. F. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Organ Chem, Ufa Res Ctr, Ufa 450054, Russia

[2] Bashkir State Agr Univ, Bashkortostan, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2010年 / 36卷 / 02期

关键词：

anti-inflammatory activity; Beckman rearrangement; diene adducts; lactams; levopimaric acid; oximes; quinopimaric acid; toxicity;

D O I：

10.1134/S1068162010020160

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Under the action of PCl(5), the Beckman rearrangement of a 3: 1 mixture of Z- and E-isomeres of 18 beta-hydro-xydihydroquinopimaric acid resulted in 5'-caprolactam and isomeric caprolactams containing fragments of cyclic ether. Z- and E-ketoximes were separated as acetates. Using a carrageenan inflammation model, we demonstrated that the anti-inflammatory activity of quinopimaric acid derivatives was comparable with that of diclofenac.

引用

页码：257 / 262

页数：6

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