Iron Overload in Survivors of Childhood Cancer

被引：10

作者：

Trovillion, Erin Murphy ^{[1
]}

Schubert, Lynn ^{[1
]}

Dietz, Andrew C. ^{[2
]}

机构：

[1] Rady Childrens Hosp, Div Pediat Hematol Oncol BMT, San Diego, CA USA

[2] Univ Southern Calif, Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Los Angeles, CA USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2018年 / 40卷 / 05期

关键词：

iron overload; childhood cancer; survivorship; BONE-MARROW-TRANSPLANTATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; LONG-TERM SURVIVORS; LIVER DYSFUNCTION; CHILDREN; THERAPY; HEALTH; CARE;

D O I：

10.1097/MPH.0000000000000887

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background:Patients transfused with packed red blood cells (PRBC), including childhood cancer survivors (CCS), experience complications. We describe iron overload (ferritin>500 ng/mL) prevalence and identify risk factors in CCS.Observations:Of 116 participants, 3 (2.6%) had elevated ferritin. All were teenagers at cancer diagnosis and received >8000 mL PRBC. Total PRBC volume correlated best with elevated ferritin (r=0.74; P<0.0001). PRBC (8000 mL) had the best positive and negative predictive value (75% and 100%, respectively) for iron overload.Conclusions:CCS may have iron overload. Overall prevalence is low. At-risk include teenagers at diagnosis and those receiving higher total PRBC volumes.

引用

页码：396 / 400

页数：5

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