Whole-Brain Mapping the Direct Inputs of Dorsal and Ventral CA1 Projection Neurons

被引：29

作者：

Tao, Sijue ^{[1
,2
]}

Wang, Yihang ^{[2
]}

Peng, Jundan ^{[2
]}

Zhao, Yang ^{[2
]}

He, Xiaobin ^{[2
,3
]}

Yu, Xuefeng ^{[5
]}

Liu, Qing ^{[2
,3
,4
,6
]}

Jin, Sen ^{[5
]}

Xu, Fuqiang ^{[1
,2
,3
,4
,6
,7
]}

机构：

[1] Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan, Peoples R China

[2] Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst,Innovat Acad P, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan, Peoples R China

[3] Univ Chinese Acad Sci, Beijing, Peoples R China

[4] Chinese Acad Sci, Guangdong Prov Key Lab Brain Connectome & Behav, CAS Key Lab Brain Connectome & Manipulat,Shenzhen, Shenzhen Key Lab Neuropsychiat Modulat,Brain Cogn, Shenzhen, Peoples R China

[5] Chinese Acad Sci, Mat & Interfaces Ctr, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China

[6] Shenzhen Fundamental Res Inst, Shenzhen Hong Kong Inst Brain Sci, Shenzhen, Peoples R China

[7] Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China

来源：

FRONTIERS IN NEURAL CIRCUITS | 2021年 / 15卷

基金：

中国国家自然科学基金;

关键词：

dorsal CA1; ventral CA1; projection neurons; direct inputs; rabies virus tracing;

D O I：

10.3389/fncir.2021.643230

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The CA1, an important subregion of the hippocampus, is anatomically and functionally heterogeneous in the dorsal and ventral hippocampus. Here, to dissect the distinctions between the dorsal (dCA1) and ventral CA1 (vCA1) in anatomical connections, we systematically analyzed the direct inputs to dCA1 and vCA1 projection neurons (PNs) with the rabies virus-mediated retrograde trans-monosynaptic tracing system in Thy1-Cre mice. Our mapping results revealed that the input proportions and distributions of dCA1 and vCA1 PNs varied significantly. Inside the hippocampal region, dCA1 and vCA1 PNs shared the same upstream brain regions, but with distinctive distribution patterns along the rostrocaudal axis. The intrahippocampal inputs to the dCA1 and vCA1 exhibited opposite trends, decreasing and increasing gradually along the dorsoventral axis, respectively. For extrahippocampal inputs, dCA1 and vCA1 shared some monosynaptic projections from certain regions such as pallidum, striatum, hypothalamus, and thalamus. However, vCA1, not dCA1, received innervations from the subregions of olfactory areas and amygdala nuclei. Characterization of the direct input networks of dCA1 and vCA1 PNs may provide a structural basis to understand the differential functions of dCA1 and vCA1.

引用

页数：16