Eremophilane-Type Sesquiterpenes from the Fungus Xylaria sp BCC 21097

被引：59

作者：

Isaka, Masahiko ^{[1
]}

Chinthanom, Panida ^{[1
]}

Boonruangprapa, Tanapong ^{[1
]}

Rungjindamai, Nattawut ^{[1
]}

Pinruan, Umpava ^{[1
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol BIOTEC, Klongluang 12120, Pathumthani, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 04期

关键词：

SOUTH CHINA SEA; (+)-DIHYDROCANADENSOLIDE; LACTONES;

D O I：

10.1021/np100030x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new eremophilane-type sesquiterpenoids (1-5, 7, and 8) and the known mairetolide F (6) were isolated from the endophytic Xylaria sp. BCC 21097. A new furofurandione (9) was also isolated from the fungal extract. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical reaction studies. Eremophilanolides possessing an alpha-methylene-gamma-lactone (1-3) exhibited moderate cytotoxic activities, while related analogues bearing an endo double bond (6 and 7) were inactive.

引用

页码：683 / 687

页数：5

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