Current strategies for engineering drug nanoparticles

被引：130

作者：

Date, AA ^{[1
]}

Patravale, VB

机构：

[1] Univ Bombay, Inst Chem Technol, Div Pharmaceut, Bombay 400019, Maharashtra, India

[2] Bombay Coll Pharm, Dept Pharmaceut, Bombay 400098, Maharashtra, India

来源：

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE | 2004年 / 9卷 / 3-4期

关键词：

hydrophobic drugs; media milling; high-pressure homogenization; microemulsion; supercritical fluids;

D O I：

10.1016/j.cocis.2004.06.009

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Engineering drug itself in nanoparticulate form has emerged as a new strategy for the delivery of hydrophobic drugs due to their unique advantages over colloidal drug carriers. The current review outlines the importance and the potential of drug nanoparticles and emphasizes upon the various technologies that have been addressed in literature. Among the technologies investigated so far, media milling and high-pressure homogenization have been very well studied. Moreover, they have enabled successful commercialization of drug nanoparticles. Recently, the engineering of drug nanoparticles using microemulsification, supercritical fluids, aerosols and reactive precipitation has been successfully achieved. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：222 / 235

页数：14

共 49 条

[41] Synthesis and characterization of silica-coated iron oxide nanoparticles in microemulsion: The effect of nonionic surfactants [J].

Santra, S ;

Tapec, R ;

Theodoropoulou, N ;

Dobson, J ;

Hebard, A ;

Tan, WH .

LANGMUIR, 2001, 17 (10) :2900-2906

[42] Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis [J].

Schöler, N ;

Krause, K ;

Kayser, O ;

Müller, RH ;

Borner, K ;

Hahn, H ;

Liesenfeld, O .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (06) :1771-1779

[43]

SHANTHAKUMAR TR, 2004, P INT S ADV TECHN BU, V5, P75

[44] Cyclodextrins: Their future in drug formulation and delivery [J].

Stella, VJ ;

Rajewski, RA .

PHARMACEUTICAL RESEARCH, 1997, 14 (05) :556-567

[45] Preparation of griseofulvin nanoparticles from water-dilutable microemulsions [J].

Trotta, M ;

Gallarate, M ;

Carlotti, ME ;

Morel, S .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 254 (02) :235-242

[46]

VEMAVARAPU CC, 2002, AAPS PHARMSCI TECH, V3

[47] Synthesis of palladium nanoparticles in water-in-oil microemulsions [J].

Wang, CC ;

Chen, DH ;

Huang, TC .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2001, 189 (1-3) :145-154

[48]

Young TJ, 2004, AAPS PHARMSCITECH, V5

[49] Rapid expansion from supercritical to aqueous solution to produce submicron suspensions of water-insoluble drugs [J].

Young, TJ ;

Mawson, S ;

Johnston, KP ;

Henriksen, IB ;

Pace, GW ;

Mishra, AK .

BIOTECHNOLOGY PROGRESS, 2000, 16 (03) :402-407

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