The ABC of clinical and experimental adjuvants-A brief overview

被引：107

作者：

Brunner, Richard ^{[1
]}

Jensen-Jarolim, Erika ^{[1
]}

Pali-Schoell, Isabella ^{[1
]}

机构：

[1] Med Univ Vienna, IPP Dept Pathophysiol, Vienna, Austria

来源：

IMMUNOLOGY LETTERS | 2010年 / 128卷 / 01期

基金：

奥地利科学基金会;

关键词：

Adjuvant; Immune response; Aluminum; MF59; Monophosphoryl lipid A; Poly-lactid-co-glycolid acid; Virosomes; Freund's adjuvant; Nanoparticles; Cholera toxin B; Flagellin; MONOPHOSPHORYL-LIPID-A; TOLL-LIKE RECEPTOR; T-CELL RESPONSES; TOXIN B-SUBUNIT; HUMORAL IMMUNE-RESPONSES; INFLUENZA VACCINE; DENDRITIC CELLS; ORAL IMMUNIZATION; ANTIBODY-RESPONSES; ADAPTIVE IMMUNITY;

D O I：

10.1016/j.imlet.2009.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adjuvants are compounds that can increase and/or modulate the intrinsic immunogenicity of an antigen and elicit strong and long lasting immune responses. During the last 80 years many adjuvants have been used in experimental settings, but due to various shortcomings of most of them only aluminum compounds made it into regular clinical usage. However, during the last years promising candidates have arisen that may finally adjunct or displace aluminum substances as main adjuvant. This review summarizes information on adjuvants currently used in clinical as well as in experimental settings. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：29 / 35

页数：7

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