Successful treatment of resistant HCV in a patient with Child-Pugh B cirrhosis using sofosbuvir and glecaprevir/pibrentasvir

被引:0
作者
Islam, Munim [1 ]
Nicholas, Sarah [2 ]
Oakley, Rhys [3 ]
Healy, Brendan [4 ]
机构
[1] Univ Hosp Wales Healthcare NHS Trust, Microbiol Infect Dis, Cardiff, Wales
[2] Univ Hosp Wales Healthcare NHS Trust, Infect Dis, Cardiff, Wales
[3] Univ Hosp Wales Healthcare NHS Trust, Pharm, Cardiff, Wales
[4] Publ Hlth Wales NHS Trust, Microbiol Infect Dis, Cardiff, Wales
关键词
hepatitis and other GI infections; infections; hepatitis C; drugs: infectious diseases; CHRONIC HEPATITIS-C;
D O I
10.1136/bcr-2019-232931
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Treatments for hepatitis C are now well tolerated with very high rates of sustained virological response and almost all patients have a suitable and effective treatment option. However, treatment options remain limited for a minority of patients and are limited for patients with Child-Pugh B or C cirrhosis due to the risk of decompensation with protease inhibitors. We present a case of successful treatment with glecaprevir/pibrentasvir (Maviret) and sofosbuvir in a patient with Child-Pugh B cirrhosis and resistant virus who had failed three previous attempts of treatment including two courses of direct acting antiviral agents and in whom liver transplantation was deemed unsuitable. We propose that the balance of risks favours a trial of treatment with protease inhibitors in some circumstances in patients with Child-Pugh B cirrhosis where no other suitable alternatives including treatment post liver transplantation are available/appropriate.
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页数:4
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