High-Dose Therapy and Stem Cell Transplantation

被引：4

作者：

Zinzani, Pier Luigi ^{[1
]}

机构：

[1] Univ Bologna, Policlin S Orsola Malpighi, I-40138 Bologna, Italy

来源：

SEMINARS IN HEMATOLOGY | 2010年 / 47卷 / 02期

关键词：

COMPLETE REMISSION; MOLECULAR REMISSIONS; HEMATOPOIETIC-CELLS; LYMPHOMA; CHEMOTHERAPY; EXPERIENCE; PTCL;

D O I：

10.1053/j.seminhematol.2010.01.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Results of conventional or high-dose chemotherapy for peripheral T-cell lymphoma (PTCL) are unsatisfactory, leaving a potential role for autologous or allogeneic stem cell transplantation. There are a number of retrospective studies and a few prospective studies On autologous transplantation for first-line PTCL treatment. Studies show that autologous transplant is feasible in relapsed and previously untreated patients, and efficacy is comparable to results in aggressive B-cell lymphomas. Allogeneic transplant may also have a role in relapsed PTCL, especially in the context of reduced-intensity conditioning, which has decreased nonrelapse mortality. However, it is unclear whether there is a role for allogeneic transplant as a frontline treatment option. Semin Hematol 47:S15-S17. (C) 2010 Published by Elsevier Inc.

引用

页码：S15 / S17

页数：3

共 15 条

[1] Allogeneic stem cell transplantation following reduced-intensity conditioning can induce durable clinical and molecular remissions in relapsed lymphomas: pre-transplant disease status and histotype heavily influence outcome [J].

Corradini, P. ;

Dodero, A. ;

Farina, L. ;

Fanin, R. ;

Patriarca, F. ;

Miceli, R. ;

Matteucci, P. ;

Bregni, M. ;

Scime, R. ;

Narni, F. ;

Pogliani, E. ;

Locasciulli, A. ;

Milani, R. ;

Carniti, C. ;

Bacigalupo, A. ;

Rambaldi, A. ;

Bonifazi, F. ;

Olivieri, A. ;

Gianni, A. M. ;

Tarella, C. .

LEUKEMIA, 2007, 21 (11) :2316-2323

[2] Long-term follow-up of patients with peripheral T-cell lymphomas treated up-front with high-dose chemotherapy followed by autologous stem cell transplantation [J].

Corradini, P. ;

Tarella, C. ;

Zallio, F. ;

Dodero, A. ;

Zanni, M. ;

Valagussa, P. ;

Gianni, A. M. ;

Rambaldi, A. ;

Barbui, T. ;

Cortelazzo, S. .

LEUKEMIA, 2006, 20 (09) :1533-1538

[3] Graft-versus-lymphoma effect in relapsed peripheral T-cell non-Hodgkin's lymphomas after reduced-intensity conditioning followed by allogeneic transplantation of hematopoietic cells [J].

Corradini, P ;

Dodero, A ;

Zallio, F ;

Caracciolo, D ;

Casini, M ;

Bregni, M ;

Narni, F ;

Patriarca, F ;

Boccadoro, M ;

Benedetti, F ;

Rambaldi, A ;

Gianni, AM ;

Tarella, C .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (11) :2172-2176

[4] Reduced-intensity conditioning followed by allografting of hematopoietic cells can produce clinical and molecular remissions in patients with poor-risk hematologic malignancies [J].

Corradini, P ;

Tarella, C ;

Olivieri, A ;

Gianni, AM ;

Voena, C ;

Zallio, F ;

Ladetto, M ;

Falda, M ;

Lucesole, M ;

Dodero, A ;

Ciceri, F ;

Benedetti, F ;

Rambaldi, A ;

Sajeva, MR ;

Tresoldi, M ;

Pileri, A ;

Bordignon, C ;

Bregni, M .

BLOOD, 2002, 99 (01) :75-82

[5]

d'Amore F, 2006, BLOOD, V108, p123A

[6] The role of high-dose therapy and stem cell rescue in the management of T-cell malignant lymphomas: a BSBMT and ABMTRR study [J].

Feyler, S. ;

Prince, H. M. ;

Pearce, R. ;

Towlson, K. ;

Nivison-Smith, I. ;

Schey, S. ;

Gibson, J. ;

Patton, N. ;

Bradstock, K. ;

Marks, D. I. ;

Cook, G. .

BONE MARROW TRANSPLANTATION, 2007, 40 (05) :443-450

[7]

Khouri IF, 2008, BLOOD, V112, P417

[8] Myeloablative allogeneic hematopoietic stem cell transplantation for non-Hodgkin lymphoma: a nationwide survey in Japan [J].

Kim, Sung-Won ;

Tanimoto, Tetsuya E. ;

Hirabayashi, Noriyuki ;

Goto, Seiichi ;

Kami, Masahiro ;

Yoshioka, Satoshi ;

Uchida, Toshiki ;

Kishi, Kenji ;

Tanaka, Yuji ;

Kohno, Akio ;

Kasai, Masaharu ;

Higuchi, Masakazu ;

Kasai, Masanobu ;

Mori, Shin-ichiro ;

Fukuda, Takahiro ;

Izutsu, Koji ;

Sao, Hiroshi ;

Ishikawa, Takayuki ;

Ichinohe, Tatsuo ;

Takeuchi, Kengo ;

Tajima, Kinuko ;

Tanosaki, Ryuji ;

Harada, Mine ;

Taniguchi, Shuichi ;

Tobinai, Kensei ;

Hotta, Tomomitsu ;

Takaue, Yoichi .

BLOOD, 2006, 108 (01) :382-389

[9] High-dose therapy and autologous stem-cell transplantation in angioimmunoblastic lymphoma: Complete remission at transplantation is the major determinant of outcome - Lymphoma working party of the European group for blood and marrow transplantation [J].

Kyriakou, Charalampia ;

Canals, Carmen ;

Goldstone, Anthony ;

Caballero, Dolores ;

Metzner, Bernd ;

Kobbe, Guido ;

Kolb, Hans-Jochem ;

Kienast, Joachim ;

Reimer, Peter ;

Finke, Jurgen ;

Oberg, Gunnar ;

Hunter, Ann ;

Theorin, Niklas ;

Sureda, Anna ;

Schmitz, Norbert .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (02) :218-224

[10] Intensive chemotherapy (high-dose CHOP/ESHAP regimen) followed by autologous stem-cell transplantation in previously untreated patients with peripheral T-cell lymphoma [J].

Mercadal, S. ;

Briones, J. ;

Xicoy, B. ;

Pedro, C. ;

Escoda, L. ;

Estany, C. ;

Camos, M. ;

Colomo, L. ;

Espinosa, I. ;

Martinez, S. ;

Ribera, J. M. ;

Martino, R. ;

Gutierrez-Garcia, G. ;

Montserrat, E. ;

Lopez-Guillermo, A. .

ANNALS OF ONCOLOGY, 2008, 19 (05) :958-963

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