Better nephrology for mice-and man

被引：34
作者：
Breyer, Matthew D. [1 ]
Qi, Zhonghua [1 ]
机构：
[1] Eli Lilly & Co, Lilly Res Labs, Biotechnol Discovery Res, Indianapolis, IN 46285 USA
来源：
KIDNEY INTERNATIONAL | 2010年 / 77卷 / 06期
关键词：
GLOMERULAR-FILTRATION-RATE; SERUM CREATININE; RENAL-FUNCTION; CLEARANCE;
D O I：
10.1038/ki.2009.544
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The use of creatinine to estimate glomerular filtration rate in patients is prone to well-described artifacts that impact its interpretation. Eisner et al. now show that the impact of creatinine secretion on creatinine clearance is even larger in mice than in humans, raising questions regarding the utility of creatinine for measuring glomerular filtration rate in mice. Kidney International (2010) 77, 487-489. doi: 10.1038/ki.2009.544
引用
收藏
页码：487 / 489
页数：4
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