Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease

被引：14

作者：

Nishijima, Yoko ^{[1
]}

Kobori, Hiroyuki ^{[2
]}

Kaifu, Kumiko ^{[1
]}

Mizushige, Tomoko ^{[2
]}

Hara, Taiga ^{[1
]}

Nishiyama, Akira ^{[2
]}

Kohno, Masakazu ^{[1
]}

机构：

[1] Kagawa Univ, Fac Med, Dept Cardiorenal & Cerebrovasc Med, Miki, Kagawa, Japan

[2] Kagawa Univ, Fac Med, Dept Pharmacol, Miki, Kagawa, Japan

来源：

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | 2014年 / 15卷 / 04期

关键词：

Angiotensinogen; circadian rhythm; healthy volunteers; CKD; plasma; urine; SALT-SENSITIVE RATS; INTRARENAL ANGIOTENSINOGEN; RENAL INJURY; HYPERTENSION; RENIN; PHYSIOLOGY; BIOMARKER; SYSTEM; TIME;

D O I：

10.1177/1470320314557584

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The urinary angiotensinogen (AGT) excretion rate could be a novel biomarker for the intrarenal activity of the renin-angiotensin system. Little is known about the circadian rhythm of AGT levels in plasma or urine. In this short article, making use of data in plasma and urine of healthy volunteers and patients with chronic kidney diseases, we first report that we were unable to find evidence for a circadian rhythm of AGT under any condition. Next we critically discuss to what degree elevated urinary AGT levels might be considered an independent biomarker that is not simply the non-specific consequence of proteinuria.

引用

页码：505 / 508

页数：4

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